Inspiratory Stridor
Bernadette L. Koch, MD
DIFFERENTIAL DIAGNOSIS
Common
Croup
Foreign Body, Esophagus
Exudative Tracheitis
Subglottic Hemangioma
Less Common
Innominate Artery Compression Syndrome
Congenital Tracheal Stenosis
Iatrogenic Tracheal Stenosis
Rare but Important
Epiglottitis, Child
Right Arch with Aberrant Left SCA
Foreign Body, Trachea
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Stridor: Variably pitched respiratory sound caused by tissue vibration through area of respiratory tract of decreased caliber
Helpful Clues for Common Diagnoses
Croup
Key facts
Viral etiology; barky cough
Most common at age 6 months-3 years; peak 1 year
Imaging
AP radiograph: Symmetric subglottic tracheal narrowing produces lack of normal “shouldering” of subglottic trachea; results in “steeple” sign
Lateral radiograph: Hypopharyngeal distension and ill-defined narrow subglottic airway
Radiographs obtained to exclude other causes of stridor: Exudative tracheitis, epiglottitis, aspirated foreign body (FB), or subglottic hemangioma
Foreign Body, Esophagus
Key facts
Coins are most common radiopaque FB in esophagus
If not passed, causes edema anterior to esophagus and around trachea; results in inspiratory stridor
Most common site: Upper thoracic esophagus followed by level of arch/carina and distal esophagus
Button batteries show 2-layered margin; require emergent removal to prevent caustic esophageal burn injury
Imaging
If radiodense, see FB posterior to trachea
± thickening of soft tissue between esophagus and trachea
± anterior displacement of trachea
± tracheal narrowing at level of FB
Exudative Tracheitis
Key facts
Purulent infection → intratracheal exudates may slough & occlude airway
Usually older than patients with croup
Imaging
Symmetric (or asymmetric) subglottic narrowing
± linear, soft tissue densities (membranes) within trachea ± tracheal wall irregularities (plaques)
Subglottic Hemangioma
Key facts
Inspiratory stridor, airway obstruction, hoarseness or abnormal cry; usually younger than 6 months
Associated with cutaneous hemangiomas in up to 50% of patients
7% of patients with PHACE syndrome have subglottic hemangioma
Imaging
Asymmetric subglottic tracheal narrowing on radiographs
Enhancing soft tissue mass on CT or MR
Helpful Clues for Less Common Diagnoses
Innominate Artery Compression Syndrome
Key facts
Infantile trachea lacks rigidity
Symptoms: Stridor, apnea, dyspnea; usually resolve as child grows
Increased incidence with esophageal atresia; dilated esophageal pouch deviates trachea forward, innominate artery compresses anterior trachea
Imaging
Anterior tracheal narrowing at crossing innominate artery; below thoracic inlet
Congenital Tracheal Stenosis
Key facts
Secondary to complete cartilaginous rings ± associated anomalies such as vascular ring
Imaging
Small caliber round (rather than horse shoe-shaped) trachea on cross sectional imaging
Inverted T-shaped carina on conventional radiograph or coronal reformatted CT images
Focal or diffuse stenosis possible
Iatrogenic Tracheal Stenosis
Key facts: History of prior endotracheal tube (ET) intubation, tracheostomy, or other injury
Imaging: Subglottic tracheal narrowing at level of prior ET tube or tracheostomy tube
Smooth focal narrowing (ET tube) or irregular longer narrowing (tracheostomy secondary to granulation tissue ± structural damage to tracheal rings)
Helpful Clues for Rare Diagnoses
Epiglottitis, Child
Key facts
Life threatening infectious inflammation and swelling of epiglottis and supraglottic structures
Abrupt onset of stridor, dysphagia, high fever, sore throat, dysphonia, hoarseness, and drooling
Symptoms of airway obstruction markedly increase when recumbent; do lateral radiograph in upright position
Incidence markedly decreased since H. influenzae vaccination became universal
Imaging
Enlargement of epiglottis & thickening of aryepiglottic folds on lateral X-ray
Right Arch with Aberrant Left SCA
Key facts: 0.1% of general population but usually asymptomatic
Rarely associated with tightly constricting left ligamentum arteriosum; presents with congenital stridor
Posterior esophageal indentation by aberrant SCA may cause dysphagia or feeding difficulties in infants
Imaging
Posterior esophageal indentation by aberrant SCA on esophagram
Aberrant SCA coursing posterior to esophagus on CT or MR
Foreign Body, Trachea
Key facts
Bronchial FB much more common than tracheal FB
Most airway FB not radiopaque; majority peanuts and carrots
Incident usually not witnessed
Imaging
If radiodense, identify FB in airwayStay updated, free articles. Join our Telegram channel
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