Preeclampsia is a disorder characterized by the onset of hypertension and proteinuria during pregnancy. Preeclampsia affects 3-10% of pregnancies and is a leading cause of maternal and fetal morbidity and mortality. However, despite decades of research efforts, the etiology of the disorder remains largely unknown. The pathogenesis of preeclampsia may be represented by a complex combination of vascular, genetic, immunologic, or environmental factors and is likely not explained by a single mechanism.

Investigation of the genetic etiology of preeclampsia has largely focused on candidate genes related to thrombophilias, folate metabolism, lipid metabolism, oxidative stress, and the renin-angiotensin system. To date, these genetic studies have not yielded consistent results and investigation of additional candidate pathways is warranted.

One such pathway is the solute carrier (SLC) family of transporters. SLC gene products transport sugars, amino acids, and inorganic ions across cell membranes. In general, transporters play a significant role in cellular homeostasis. During pregnancy, the placenta regulates the transfer of nutrients, solutes, and water between maternal and fetal blood and members of the SLC family of transporters likely play a role in this process.

Additionally, altered SLC transport in the maternal endothelium of the vasculature of the kidney and other organs may play an important role in preeclampsia. Abnormalities in SLC function in the kidney or placenta may be related to the volume abnormalities observed with this disease.

For these reasons, this study aimed to investigate whether 263 haplotype tagging single-nucleotide polymorphisms (SNPs) in 26 members of the SLC gene family are associated with preeclampsia in white and black women. To the best of our knowledge, a search of the published literature prior to February 2010 using the search terms “preeclampsia,” “gene,” and “solute carrier” revealed that no other study has investigated the role of SLC gene polymorphisms in preeclampsia.

Materials and Methods

Study population

At the Hospital of the University of Pennsylvania, the Preeclampsia: Mechanisms and Consequences case-controlled study was developed between March 2005 and August 2007. Cases were women with mild or severe preeclampsia. Controls were enrolled from women without pregnancy-related hypertension who presented for delivery at term (≥37 weeks) for spontaneous rupture of membranes, term labor, induction of labor, or cesarean section. Cases and controls were matched for self-reported race (black vs other). Institutional review board approval was obtained from the University of Pennsylvania School of Medicine prior to enrollment. Additional descriptions of this study are provided elsewhere.

Preeclampsia phenotype

Cases were identified based on prespecified maternal criteria for preeclampsia according to standard criteria of the American College of Obstetrics and Gynecology. Preeclampsia was defined as elevated blood pressure (≥140/90 mm Hg on 2 measurements ≥6 hours apart or ≥160/105 mm Hg on presentation) with new onset of proteinuria. Women who had gestational hypertension or chronic hypertension with superimposed preeclampsia were also eligible to be cases. Based on these prespecified criteria, case eligibility was determined at the time of enrollment and not by the treating physician. A total of 218 cases and 413 controls were recruited and represented 6 ethnic groups. Whites (n = 31 cases and n = 85 controls) and blacks (n = 181 cases and n = 303 controls) were evaluated in this study.

Measurements

Trained research nurses collected information on height, race, ethnicity, and history of hypertension by patient interview at the time of enrollment. Specifically, race and ethnicity were designated based on self-report. Additional medical history was collected from prenatal and hospital chart abstraction by trained research nurses. A separate individual performed data entry and all data were reviewed by 1 of the study’s primary investigators for completeness, consistency, and accuracy.

Genotyping methodology

Maternal deoxyribonucleic acid was derived from whole-blood samples, collected by phlebotomy. Specimens were stored and then processed within approximately 6 hours of collection. Samples were genotyped for the Illumina IBCv2 (San Diego, CA) array containing 50,000 gene-centric SNPs selected for their relevance to cardiovascular, metabolic, and inflammatory syndromes. From the panel of genotyped SNPs, this study focused on 263 haplotype tagging SNPs in 26 SLC genes ( Supplemental Table ). Forty-six SNPs were monomorphic in whites, resulting in a total of 217 SNPs available for analysis in this ethnic group. One SNP was monomorphic in blacks, resulting in a total of 262 SNPs available in this ethnic group.

TABLE SUPPLEMENTAL

263 haplotype tagging SNPs in 26 SLC genes evaluated in blacks and whites

				Blacks		Whites
Gene	SNP ID	Gene region	Alleles	Allele frequency	HWE	Allele frequency	HWE
SLC10A4	rs11945562	Intronic	C/T	0.31/0.69	NS	0.54/0.46	NS
SLC10A4	rs13114836	Intronic	C/G	0.20/0.80	NS	0.21/0.79	NS
SLC10A4	rs1565217	N/A	A/G	0.40/0.60	NS	0.25/0.75	NS
SLC10A4	rs1565218	N/A	A/G	0.98/0.02	NS	0.96/0.04	NS
SLC10A4	rs17472113	Intronic	A/T	0.08/0.92	NS	0.26/0.74	NS
SLC10A4	rs17609740	Intronic	A/G	0.02/0.98	NS	0.04/0.96	NS
SLC10A4	rs6838613	N/A	C/T	0.46/0.54	NS	0.54/0.46	NS
SLC10A4	rs9993088	Intronic	G/T	0.54/0.46	NS	0.74/0.26	NS
SLC10A5	rs2955003	5′ UTR	A/T	0.23/0.77	NS	0.48/0.52	NS
SLC10A5	rs2955004	5′ UTR	C/G	0.45/0.55	NS	0.39/0.61	NS
SLC10A5	rs6415649	3′ UTR	A/G	0.07/0.93	NS	0.13/0.87	NS
SLC10A5	rs6995098	Synonymous	A/G	0.88/0.13	NS	0.96/0.04	NS
SLC11A2	rs11169658	Intronic	A/G	0.93/0.07	NS	0.99/0.01	NS
SLC11A2	rs12312876	Intronic	A/C	0.94/0.06	NS	1.00/0.00	NA
SLC11A2	rs161046	Intronic	A/G	0.16/0.84	NS	0.06/0.94	NS
SLC11A2	rs17125212	Intronic	C/G	0.90/0.10	NS	1.00/0.00	NA
SLC11A2	rs224446	3′ UTR	C/T	0.84/0.16	NS	0.86/0.14	NS
SLC11A2	rs2285230	3′ UTR	A/G	0.94/0.06	NS	0.81/0.19	NS
SLC12A1	rs10851463	Intronic	G/T	0.16/0.84	NS	0.90/0.10	NS
SLC12A1	rs11636073	Intronic	A/T	0.36/0.64	NS	0.86/0.14	NS
SLC12A1	rs12593807	Intronic	C/T	0.55/0.45	NS	0.14/0.86	NS
SLC12A1	rs12907018	Intronic	A/G	0.53/0.47	NS	0.09/0.91	NS
SLC12A1	rs1320052	3′ UTR	A/G	0.45/0.55	NS	0.99/0.01	NS
SLC12A1	rs1484552	Intronic	C/T	0.90/0.10	NS	0.99/0.01	NS
SLC12A1	rs1531916	Intronic	C/T	0.40/0.60	NS	0.18/0.82	NS
SLC12A1	rs16960661	Intronic	A/G	0.72/0.28	NS	0.99/0.01	NS
SLC12A1	rs16960679	Intronic	C/T	0.70/0.30	NS	0.99/0.01	NS
SLC12A1	rs16960680	Intronic	A/G	0.11/0.89	NS	0.00/1.00	NA
SLC12A1	rs16960681	Intronic	C/T	0.06/0.94	NS	0.01/0.99	NS
SLC12A1	rs16960682	Intronic	C/G	0.01/0.99	NS	0.02/0.98	NS
SLC12A1	rs16960698	Intronic	C/T	0.76/0.24	NS	0.96/0.04	NS
SLC12A1	rs17350938	Intronic	A/G	0.91/0.09	NS	0.87/0.13	NS
SLC12A1	rs2279366	Intronic	A/G	0.55/0.45	NS	0.18/0.82	NS
SLC12A1	rs2279369	Intronic	A/G	0.09/0.91	NS	0.13/0.87	NS
SLC12A1	rs3784614	Intronic	C/T	0.83/0.17	NS	0.99/0.01	NS
SLC12A1	rs4082950	Intronic	C/G	0.09/0.91	NS	0.00/1.00	NA
SLC12A1	rs6493317	Intronic	C/T	0.58/0.42	NS	0.22/0.78	NS
SLC12A1	rs7179027	Intronic	A/G	0.57/0.43	NS	0.78/0.22	NS
SLC12A1	rs8028035	Intronic	A/G	0.83/0.17	NS	1.00/0.00	NA
SLC12A1	rs8032941	Intronic	A/G	0.85/0.15	NS	1.00/0.00	NA
SLC12A1	rs8033546	Intronic	C/T	0.83/0.17	NS	0.96/0.04	NS
SLC12A1	rs9806541	Intronic	G/T	0.10/0.90	NS	0.00/1.00	NA
SLC12A1	rs9806747	Intronic	A/C	0.08/0.92	NS	0.00/1.00	NA
SLC12A1	rs9920281	Intronic	A/G	0.33/0.67	NS	0.99/0.01	NS
SLC12A3	rs11076172	Intronic	C/T	0.91/0.09	NS	0.76/0.24	NS
SLC12A3	rs1138429	Intronic	A/T	0.98/0.02	NS	0.96/0.04	NS
SLC12A3	rs11643718	Missense	A/G	0.01/0.99	NS	0.12/0.88	NS
SLC12A3	rs12446689	Intronic	C/T	0.12/0.88	NS	0.14/0.86	NS
SLC12A3	rs12449275	Intronic	A/G	0.20/0.80	NS	0.26/0.74	NS
SLC12A3	rs12708965	Missense	C/T	0.91/0.09	NS	1.00/0.00	NA
SLC12A3	rs13306673	Intronic	C/T	0.77/0.23	NS	0.94/0.06	NS
SLC12A3	rs13306677	Intronic	C/T	0.93/0.07	NS	0.89/0.11	NS
SLC12A3	rs16963619	Intronic	A/G	0.05/0.95	NS	1.00/0.00	NA
SLC12A3	rs17367381	Intronic	A/G	0.00/1.00	NS	0.05/0.95	NS
SLC12A3	rs2099107	Intronic	A/G	0.78/0.22	NS	0.86/0.14	NS
SLC12A3	rs2304478	Intronic	C/T	1.00/0.00	NS	0.99/0.01	NS
SLC12A3	rs2304482	Intronic	A/G	0.09/0.91	NS	0.09/0.91	NS
SLC12A3	rs2304483	Intronic	A/G	0.31/0.69	NS	0.61/0.39	NS
SLC12A3	rs4567697	Intronic	G/T	0.82/0.18	NS	0.54/0.46	NS
SLC12A3	rs6499858	Intronic	C/T	0.33/0.67	NS	0.69/0.31	NS
SLC12A3	rs6499860	Intronic	A/C	0.27/0.73	NS	0.48/0.52	NS
SLC12A3	rs711746	Intronic	A/G	0.27/0.73	NS	0.47/0.53	NS
SLC12A3	rs711747	Intronic	C/G	0.41/0.59	NS	0.47/0.53	NS
SLC12A3	rs711748	Intronic	C/G	0.35/0.65	NS	0.47/0.53	NS
SLC12A3	rs7184451	Intronic	A/G	0.79/0.21	NS	0.98/0.02	NS
SLC12A3	rs7185859	Intronic	A/T	0.09/0.91	NS	0.01/0.99	NS
SLC12A3	rs7204044	Intronic	C/T	0.95/0.05	NS	0.74/0.26	NS
SLC12A3	rs8043560	Intronic	A/G	0.85/0.15	NS	0.65/0.35	NS
SLC12A3	rs8046857	Intronic	A/G	0.88/0.12	NS	0.97/0.03	NS
SLC12A3	rs8056954	Intronic	G/T	0.67/0.33	NS	0.81/0.19	NS
SLC12A3	rs8063406	Intronic	G/T	0.48/0.52	NS	0.65/0.35	NS
SLC16A1	rs1049434	Missense	A/T	0.88/0.12	NS	0.57/0.43	NS
SLC16A1	rs11801876	Intronic	A/T	0.96/0.04	NS	1.00/0.00	NA
SLC16A1	rs11804107	Intronic	G/T	0.95/0.05	NS	1.00/0.00	NA
SLC16A1	rs17030801	Intronic	C/G	0.81/0.19	NS	0.99/0.01	NS
SLC16A1	rs17030813	Intronic	C/T	0.10/0.90	NS	0.00/1.00	NA
SLC16A1	rs17030816	Intronic	C/T	0.04/0.96	NS	0.00/1.00	NA
SLC16A1	rs3849174	Intronic	G/T	0.57/0.43	NS	0.23/0.77	NS
SLC16A1	rs4301628	Intronic	A/G	0.17/0.83	NS	0.31/0.69	NS
SLC16A1	rs7512840	Intronic	A/C	0.84/0.16	NS	1.00/0.00	NA
SLC16A1	rs7519199	Intronic	C/T	0.90/0.09	NS	1.00/0.00	NA
SLC17A5	rs10943113	Intronic	G/T	0.22/0.78	NS	0.26/0.74	NS
SLC17A5	rs12528608	Intronic	G/T	0.94/0.06	NS	0.78/0.22	NS
SLC17A5	rs16883930	Missense	A/G	0.01/0.99	NS	0.02/0.98	NS
SLC17A5	rs16883995	Intronic	C/T	0.86/0.14	NS	1.00/0.00	NA
SLC17A5	rs34348416	Missense	A/G	0.99/0.01	NS	1.00/0.00	NA
SLC17A5	rs364734	Intronic	A/C	0.15/0.85	NS	0.08/0.92	NS
SLC17A5	rs4706550	Intronic	C/T	0.01/0.99	NS	0.02/0.98	NS
SLC17A5	rs589743	Intronic	A/C	0.95/0.05	NS	1.00/0.00	NA
SLC17A5	rs610260	Intronic	A/G	0.36/0.64	NS	0.09/0.91	NS
SLC17A5	rs6930349	Intronic	C/T	0.91/0.09	NS	1.00/0.00	NA
SLC19A1	rs1051266	Missense	C/T	0.36/0.64	NS	0.54/0.46	NS
SLC19A1	rs1051298	3′ UTR	A/G	0.55/0.45	NS	0.45/0.55	NS
SLC19A1	rs1888530	intronic	C/T	0.32/0.68	NS	0.55/0.45	NS
SLC19A2	rs10737546	Intronic	A/G	0.62/0.38	NS	0.77/0.23	NS
SLC19A2	rs10919175	Intronic	C/G	0.39/0.61	NS	0.27/0.73	NS
SLC19A2	rs12091844	3′ UTR	A/G	0.10/0.90	NS	0.06/0.94	NS
SLC19A2	rs16862199	3′ UTR	A/G	0.63/0.37	NS	0.82/0.18	NS
SLC19A2	rs16862217	Intronic	A/G	0.97/0.03	NS	0.99/0.01	NS
SLC19A2	rs17518769	Intronic	C/T	0.73/0.27	NS	0.93/0.07	NS
SLC19A2	rs1983546	Intronic	C/T	0.61/0.39	NS	0.39/0.61	NS
SLC19A2	rs6656463	Intronic	A/G	0.91/0.09	NS	0.62/0.38	NS
SLC19A2	rs7522245	Intronic	A/T	0.78/0.22	NS	0.42/0.58	NS
SLC20A1	rs10758	Intronic	A/G	0.74/0.26	NS	0.74/0.26	NS
SLC20A1	rs17042208	Intronic	A/G	0.91/0.09	NS	1.00/0.00	NA
SLC20A1	rs3817328	Intronic	C/G	0.96/0.04	NS	0.96/0.04	NS
SLC20A1	rs4849091	Synonymous	C/T	0.80/0.20	NS	0.45/0.55	NS
SLC20A1	rs6793	3′ UTR	A/G	0.64/0.36	NS	0.81/0.19	NS
SLC22A2	rs10755577	Intronic	A/G	0.30/0.70	NS	0.11/0.89	NS
SLC22A2	rs2450973	Intronic	A/T	0.33/0.67	NS	0.09/0.91	NS
SLC22A2	rs3103352	Intronic	A/G	0.16/0.84	NS	0.11/0.89	NS
SLC22A2	rs3127592	3′ UTR	A/G	0.84/0.16	NS	0.89/0.11	NS
SLC22A2	rs315984	Intronic	A/G	0.42/0.58	NS	0.80/0.20	NS
SLC22A2	rs315995	Intronic	C/T	0.57/0.43	NS	0.20/0.80	NS
SLC22A2	rs316000	Intronic	C/T	0.36/0.64	NS	0.19/0.81	NS
SLC22A2	rs316002	Intronic	A/G	0.03/0.97	NS	0.20/0.80	NS
SLC22A2	rs316009	Intronic	A/G	0.09/0.91	NS	0.08/0.92	NS
SLC22A2	rs316019	Missense	A/C	0.16/0.84	NS	0.08/0.92	NS
SLC22A2	rs316021	Intronic	C/T	0.52/0.48	NS	0.20/0.80	NS
SLC22A2	rs3798156	Intronic	A/G	0.13/0.87	NS	0.12/0.88	NS
SLC22A2	rs3798158	Intronic	T/G	0.00/1.00	NS	0.04/0.96	NS
SLC22A2	rs3912161	Intronic	T/C	0.01/0.99	NS	0.06/0.94	NS
SLC22A2	rs624249	Synonymous	A/C	0.23/0.77	NS	0.42/0.58	NS
SLC22A2	rs8177516	Missense	C/T	0.98/0.02	NS	1.00/0.00	NA
SLC22A2	rs8177517	Missense	A/C	0.97/0.03	NS	0.99/0.01	NS
SLC22A5	rs10040427	Missense	A/G	0.06/0.94	NS	1.00/0.00	NA
SLC22A5	rs17622208	Intronic	C/T	0.81/0.19	NS	0.52/0.48	NS
SLC22A5	rs2073642	Intronic	A/G	0.06/0.94	<0.001	0.07/0.93	NS
SLC22A5	rs2073643	Intronic	C/T	0.40/0.60	NS	0.56/0.44	NS
SLC22A5	rs274550	Intronic	G/T	0.58/0.42	NS	0.14/0.86	NS
SLC22A5	rs274558	Synonymous	C/T	0.34/0.66	NS	0.37/0.63	NS
SLC22A5	rs274562	Intronic	C/G	0.74/0.26	NS	0.64/0.36	NS
SLC25A20	rs12493289	Intronic	A/G	0.51/0.49	NS	0.71/0.29	NS
SLC25A20	rs35989076	Missense	C/T	0.99/0.01	NS	1.00/0.00	NA
SLC2A10	rs11086177	Intronic	C/T	0.36/0.64	NS	0.06/0.94	NS
SLC2A10	rs2235491	Missense	A/G	0.25/0.75	NS	0.06/0.94	NS
SLC2A10	rs2425903	Intronic	A/G	0.59/0.41	NS	0.41/0.59	NS
SLC2A10	rs3091904	Intronic	A/G	0.64/0.36	NS	0.55/0.45	NS
SLC2A10	rs34295241	Missense	C/T	0.99/0.01	NS	1.00/0.00	NA
SLC2A10	rs6094438	Missense	A/C	0.04/0.96	NS	1.00/0.00	NA
SLC2A10	rs7267790	Intronic	C/T	0.94/0.06	NS	0.99/0.01	NS
SLC2A10	rs7348121	Missense	C/T	0.08/0.92	NS	0.00/1.00	NA
SLC2A10	rs998422	Intronic	C/T	0.17/0.83	NS	0.45/0.55	NS
SLC2A2	rs10513684	Intronic	C/T	0.96/0.04	NS	0.94/0.06	NS
SLC2A2	rs10513685	Intronic	C/T	0.62/0.38	NS	0.85/0.15	NS
SLC2A2	rs11711437	Intronic	C/G	0.48/0.52	NS	0.84/0.16	NS
SLC2A2	rs11924032	Intronic	A/G	0.40/0.60	NS	0.26/0.74	NS
SLC2A2	rs11925298	Intronic	A/G	0.14/0.86	NS	0.02/0.98	NS
SLC2A2	rs12488694	Intronic	A/G	0.08/0.92	NS	0.02/0.98	NS
SLC2A2	rs16855638	Intronic	A/C	0.92/0.08	NS	1.00/0.00	NA
SLC2A2	rs5400	Missense	C/T	0.53/0.47	NS	0.85/0.15	NS
SLC2A2	rs7610064	3′ UTR	A/T	0.96/0.04	NS	1.00/0.00	NA
SLC2A2	rs9828378	Intronic	C/G	0.11/0.89	NS	0.16/0.84	NS
SLC2A4	rs16956647	Intronic	C/T	0.95/0.05	NS	0.99/0.01	NS
SLC2A4	rs222847	Intronic	A/T	0.99/0.01	NS	0.94/0.06	NS
SLC2A4	rs5435	Synonymous	A/G	0.13/0.87	NS	0.34/0.66	NS
SLC2A4	rs5436	Intronic	C/T	0.93/0.07	NS	1.00/0.00	NA
SLC2A5	rs12145292	Intronic	G/T	0.73/0.27	NS	0.69/0.31	NS
SLC2A5	rs1612895	Intronic	C/T	0.73/0.27	NS	0.45/0.55	NS
SLC2A5	rs1705295	Intronic	C/T	0.99/0.01	NS	0.92/0.08	NS
SLC2A5	rs2505972	Intronic	A/C	0.31/0.69	NS	0.65/0.35	NS
SLC2A5	rs3737661	Intronic	A/C	0.09/0.91	NS	0.06/0.94	NS
SLC2A5	rs3765962	Intronic	A/T	0.84/0.16	NS	0.73/0.27	NS
SLC2A5	rs6680123	Intronic	C/T	0.08/0.92	NS	0.00/1.00	NA
SLC2A5	rs6694527	Intronic	C/T	0.94/0.06	NS	1.00/0.00	NA
SLC2A5	rs7521322	Intronic	C/T	0.54/0.46	NS	0.39/0.61	NS
SLC2A5	rs765617	Intronic	A/G	0.47/0.53	NS	0.29/0.71	NS
SLC30A8	rs10282940	3′ UTR	A/G	0.24/0.76	NS	0.08/0.92	NS
SLC30A8	rs11558471	3′ UTR	A/G	0.91/0.09	NS	0.72/0.28	NS
SLC30A8	rs11776475	Intronic	C/T	0.13/0.87	NS	0.19/0.81	NS
SLC30A8	rs11989843	Intronic	A/G	0.73/0.27	NS	0.78/0.22	NS
SLC30A8	rs12678848	5′ UTR	C/G	0.02/0.98	NS	0.05/0.95	NS
SLC30A8	rs13266634	Missense	C/T	0.91/0.09	NS	0.72/0.28	NS
SLC30A8	rs16889438	N/A	C/T	0.78/0.22	NS	0.99/0.01	NS
SLC30A8	rs16889462	Missense	C/T	0.90/0.10	NS	0.99/0.01	NS
SLC30A8	rs17738231	Intronic	C/G	0.97/0.03	NS	0.82/0.18	NS
SLC30A8	rs2466296	Intronic	A/G	0.66/0.34	NS	0.18/0.82	NS
SLC30A8	rs2466298	Intronic	G/T	0.69/0.31	NS	0.27/0.73	NS
SLC30A8	rs3802177	3′ UTR	A/G	0.09/0.91	NS	0.28/0.72	NS
SLC30A8	rs4876370	Intronic	A/G	0.75/0.25	NS	0.78/0.22	NS
SLC30A8	rs6469675	Intronic	A/G	0.30/0.70	NS	0.72/0.28	NS
SLC30A8	rs7015338	Intronic	C/T	0.17/0.83	NS	0.22/0.78	NS
SLC39A4	rs11779952	Intronic	A/G	0.06/0.94	NS	0.06/0.94	NS
SLC39A4	rs2272658	Intronic	A/G	0.44/0.56	NS	0.48/0.52	NS
SLC39A4	rs2280838	Missense	A/G	0.42/0.58	NS	0.56/0.44	NS
SLC39A4	rs2977838	Missense	A/G	0.01/0.99	NS	0.02/0.98	NS
SLC39A4	rs7823979	Missense	A/G	0.10/0.90	NS	0.00/1.00	NA
SLC4A1	rs11870606	Intronic	A/G	0.03/0.97	NS	0.19/0.81	NS
SLC4A1	rs12942711	N/A	C/G	0.03/0.97	NS	0.00/1.00	NA
SLC4A1	rs2074107	Intronic	A/G	0.31/0.69	NS	0.17/0.83	NS
SLC4A1	rs2074108	Intronic	C/T	0.27/0.73	NS	0.62/0.38	NS
SLC4A1	rs2285643	Intronic	A/G	0.01/0.99	NS	1.00/0.00	NA
SLC4A1	rs2857078	Intronic	A/C	0.49/0.51	NS	0.34/0.66	NS
SLC4A1	rs5020	Synonymous	T/C	0.04/0.96	NS	1.00/0.00	NA
SLC4A1	rs5026	Missense	C/T	0.89/0.11	NS	1.00/0.00	NA
SLC4A1	rs5035	Missense	A/C	1.00/0.00	NS	0.96/0.04	NS
SLC4A1	rs5036	Missense	A/G	0.88/0.12	NS	0.98/0.02	NS
SLC4A1	rs7209090	N/A	A/G	0.18/0.82	NS	0.09/0.91	NS
SLC4A1	rs7222501	N/A	A/G	0.50/0.50	NS	0.41/0.59	NS
SLC4A1	rs9916116	5′ UTR	C/T	0.52/0.48	NS	0.16/0.84	NS
SLC4A5	rs17009792	Missense	C/T	0.83/0.17	NS	0.98/0.02	NS
SLC6A14	rs12393509	Intronic	A/G	0.90/0.10	NS	1.00/0.00	NA
SLC6A14	rs12710568	5′ UTR	C/G	0.79/0.21	NS	0.71/0.29	NS
SLC6A14	rs12710570	3′ UTR	A/G	0.90/0.10	NS	0.78/0.22	NS
SLC6A14	rs12720073	5′ UTR	A/G	0.69/0.31	NS	0.93/0.07	NS
SLC6A14	rs12720080	Intronic	A	1.00/0.00	NA	0.99/0.01	NS
SLC6A14	rs17242824	Intronic	G/T	0.96/0.04	<0.001	0.95/0.05	NS
SLC6A14	rs2011162	3′ UTR	C/G	0.25/0.75	NS	0.62/0.38	NS
SLC6A14	rs2011198	Intronic	G/T	0.27/0.73	NS	0.65/0.35	NS
SLC6A14	rs2032525	Intronic	C/G	0.22/0.78	NS	0.31/0.69	NS
SLC6A14	rs5905178	Intronic	A/G	0.86/0.14	NS	0.55/0.45	NS
SLC6A14	rs5905289	3′ UTR	C/T	0.85/0.15	NS	0.59/0.41	NS
SLC6A14	rs6651554	Intronic	A/G	0.93/0.07	NS	1.00/0.00	NA
SLC6A14	rs7052454	Intronic	A/G	0.95/0.05	NS	1.00/0.00	NA
SLC6A4	rs11080121	Intronic	C/T	0.21/0.79	NS	0.56/0.44	NS
SLC6A4	rs140700	Intronic	C/T	0.96/0.04	NS	0.91/0.09	NS
SLC6A4	rs140701	Intronic	C/T	0.72/0.28	NS	0.47/0.53	NS
SLC6A4	rs16965623	Intronic	C/T	0.07/0.93	NS	0.01/0.99	NS
SLC6A4	rs16965628	Intronic	C/G	0.34/0.66	NS	0.08/0.92	NS
SLC6A4	rs2020936	Intronic	A/G	0.59/0.41	NS	0.82/0.18	NS
SLC6A4	rs2020942	Intronic	C/T	0.75/0.25	NS	0.72/0.28	NS
SLC6A4	rs2066713	Intronic	C/T	0.74/0.26	NS	0.72/0.28	NS
SLC6A4	rs3794808	Intronic	C/T	0.65/0.35	NS	0.48/0.52	NS
SLC6A4	rs4251417	Intronic	C/T	0.99/0.01	NS	0.84/0.16	NS
SLC6A4	rs4583306	Intronic	C/T	0.19/0.81	NS	0.52/0.48	NS
SLC6A4	rs6353	Synonymous	A/G	0.07/0.93	NS	0.00/1.00	NA
SLC6A4	rs6355	Missense	C/G	0.00/1.00	NS	0.02/0.98	NS
SLC6A4	rs7212502	Intronic	C/T	0.09/0.91	NS	0.00/1.00	NA
SLC6A4	rs8071667	Intronic	A/G	0.25/0.75	NS	0.18/0.82	NS
SLC6A4	rs9903062	Intronic	A/G	0.04/0.96	NS	1.00/0.00	NA
SLC6A4	rs9903602	Intronic	A/C	0.51/0.49	NS	1.00/0.00	NA
SLC8A2	rs11083878	Intronic	A/G	0.44/0.56	NS	0.90/0.10	NS
SLC8A2	rs11878777	Intronic	A/G	0.42/0.58	NS	0.76/0.24	NS
SLC8A2	rs11878780	Intronic	C/T	0.81/0.19	NS	0.88/0.12	NS
SLC8A2	rs12459087	Synonymous	C/T	0.98/0.02	NS	0.91/0.09	NS
SLC8A2	rs2272295	3′ UTR	A/G	0.17/0.83	NS	0.11/0.89	NS
SLC8A2	rs4801722	Intronic	C/T	0.95/0.05	NS	1.00/0.00	NA
SLC8A2	rs4802364	Intronic	C/T	0.39/0.61	NS	0.21/0.79	NS
SLC8A2	rs4802365	Intronic	C/T	0.80/0.20	NS	0.36/0.64	NS
SLC8A2	rs830131	Intronic	C/T	0.59/0.41	NS	0.15/0.85	NS
SLC8A2	rs830142	Intronic	A/G	0.02/0.98	0.001	0.04/0.96	NS
SLC8A2	rs830162	Intronic	C/T	0.08/0.92	NS	0.10/0.90	NS
SLC9A3	rs10078774	Intronic	C/T	0.10/0.90	NS	0.20/0.80	NS
SLC9A3	rs11748410	Intronic	A/G	0.24/0.76	NS	0.05/0.95	NS
SLC9A3	rs12657631	Intronic	C/T	0.72/0.28	NS	0.54/0.46	NS
SLC9A3	rs2244223	Intronic	A/G	0.53/0.47	NS	0.62/0.38	NS
SLC9A3	rs2458814	Intronic	A/G	0.49/0.51	NS	0.46/0.54	NS
SLC9A3	rs3756711	Intronic	C/T	0.12/0.88	NS	0.13/0.87	NS
SLC9A3	rs4957061	Intronic	C/T	0.44/0.56	NS	0.41/0.59	NS
SLC9A3	rs6864158	Intronic	C/T	0.36/0.64	NS	0.34/0.66	NS
SLC9A3	rs6869782	Intronic	C/T	0.96/0.04	NS	0.72/0.28	NS
SLC9A3	rs6888815	Intronic	A/G	0.05/0.95	NS	0.01/0.99	NS
SLC9A3	rs890978	Intronic	A/G	0.69/0.31	NS	0.38/0.62	NS
SLC9A3	rs925693	Intronic	A/T	0.84/0.16	NS	0.86/0.14	NS
SLCO4C1	rs10066650	Intronic	G/T	0.15/0.85	NS	0.10/0.90	NS
SLCO4C1	rs2600827	Intronic	C/T	0.23/0.77	NS	0.21/0.79	NS
SLCO4C1	rs3811976	3′ UTR	A/G	0.91/0.09	NS	0.91/0.09	NS
SLCO4C1	rs6860754	Intronic	C/T	0.86/0.14	NS	0.90/0.10	NS
SLCO4C1	rs6884301	Intronic	A/G	0.24/0.76	NS	0.33/0.67	NS
SLCO4C1	rs6887058	Intronic	A/G	0.19/0.81	NS	0.05/0.95	NS
SLCO4C1	rs709370	Intronic	A/T	0.17/0.83	NS	0.24/0.76	NS
SLCO4C1	rs7713374	Intronic	A/C	0.98/0.02	NS	1.00/0.00	NA
SLCO4C1	rs7719298	3′ UTR	C/T	0.40/0.60	NS	0.17/0.83	NS

Only gold members can continue reading. Log In or Register to continue

Share this:

• Click to share on Twitter (Opens in new window)
• Click to share on Facebook (Opens in new window)

Related

Related posts:

1. Inadvertent rupture of benign cystic teratoma does not impair future fertility
2. Factor V Leiden mutation and pregnancy-related complications
3. Using the Brink score to predict postpartum anal incontinence
4. Evaluation of a transvaginal mesh delivery system for the correction of pelvic organ prolapse: subjective and objective findings at least 1 year after surgery

Stay updated, free articles. Join our Telegram channel

Join