CPT in pediatric respiratory diseases has been used to assist in the clearance of tracheobronchial secretions. The main goal is to clear the airway obstruction, open collapsed airways, reduce airway resistance, enhance gas exchange, and reduce the work of breathing. CPT can play a role in improving a patient’s respiratory status and expedite recovery. CPT in pediatric patients involves various techniques such as chest percussion, vibration in postural drainage positions, chest shaking, directed coughing, and slow passive forced exhalation. CPT is useful for individuals with copious mucus or thick secretions, and those with weak respiratory mechanics or those with ineffective cough. In some situations, CPT could be harmful by causing an increase in bronchospasm, inducing pulmonary hypertension, repositioning a foreign body, or destabilizing a sick infant. CPT has been linked to adverse events such as injury (rib fracture) and long term neurologic complication. But a review of the literature shows insufficient evidence of adverse events following chest physiotherapy.