Disorders of Growth




Keywords

Short stature, Failure to thrive

 


The most common reasons for deviant measurements are technical (i.e., faulty equipment and human errors). Repeating a deviant measurement is the first step. Separate growth charts are available and should be used for very low birthweight infants (weight <1,500 g) and for those with Turner syndrome, Down syndrome, achondroplasia, and various other dysmorphology syndromes.





Decision-Making Algorithm





  • Short Stature



Variability in body proportions occurs from fetal to adult life. Newborns’ heads are significantly larger in proportion to the rest of their body. This difference gradually disappears. Certain growth disturbances result in characteristic changes in the proportional sizes of the trunk, extremities, and head. Patterns requiring further assessment are summarized in Table 6.1 .



TABLE 6.1

Specific Growth Patterns Requiring Further Evaluation




















PATTERN REPRESENTATIVE DIAGNOSES TO CONSIDER FURTHER EVALUATION
Weight, length, head circumference all <5th percentile


  • Familial short stature



  • Constitutional short stature



  • Intrauterine insult



  • Genetic abnormality




  • Midparental heights



  • Evaluation of pubertal development



  • Examination of prenatal records



  • Chromosome analysis

Discrepant percentiles (e.g., weight 5th, length 5th, head circumference 50th, or other discrepancies)


  • Normal variant (familial or constitutional)



  • Endocrine growth failure



  • Caloric insufficiency




  • Midparental heights



  • Thyroid hormone



  • Growth factors, growth hormone testing



  • Evaluation of pubertal development

Declining percentiles


  • Catch-down growth



  • Caloric insufficiency



  • Endocrine growth failure




  • Complete history and physical examination



  • Dietary and social history



  • Growth factors, growth hormone testing



Evaluating a child over time, coupled with a careful history and physical examination, helps determine whether the growth pattern is normal or abnormal. Parental heights may be useful when deciding whether to proceed with a further evaluation. Children, in general, follow their parents’ growth pattern, although there are many exceptions.


For a girl, midparental height is calculated as follows:


<SPAN role=presentation tabIndex=0 id=MathJax-Element-1-Frame class=MathJax style="POSITION: relative" data-mathml='Paternal height(inches)+Maternal height(inches)2−2.5′>Paternal height(inches)+Maternal height(inches)22.5Paternal height(inches)+Maternal height(inches)2−2.5
Paternal height ( inches ) + Maternal height ( inches ) 2 − 2.5

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Jun 24, 2019 | Posted by in PEDIATRICS | Comments Off on Disorders of Growth

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