In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed:
Esplin MS, Merrell K, Goldenberg R, et al; the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units. Proteomic identification of serum peptides predicting subsequent spontaneous preterm birth. Am J Obstet Gynecol 2011;204:391.e1-8.
Discussion questions
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Was the overall study design a good choice?
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What was the Preterm Prediction Study?
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Was it reasonable to use data from the early 1990s?
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What were the main findings?
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What does ITIH4 do?
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What were the study’s strengths and weaknesses?