In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed:
Kjellberg U, van Rooijen M, Bremme K, Hellgren M. Factor V Leiden mutation and pregnancy-related complications. Am J Obstet Gynecol 2010;203:469.e1-8.
Discussion Questions
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Why is factor V Leiden (FVL) important in pregnancy?
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What was the study’s hypothesis?
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What were the details of the study design?
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What information was provided by the tables?
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Which endpoints were likely to be truly associated with FVL?
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How did the findings correspond with results from previous studies?
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How might the results change your practice approach?