Development and congenital anomalies of the gastrointestinal tract

Figure 13.1

Sagittal sections showing the cephalocaudal folding of the embryo and the formation of the primitive gut




Table 13.1 Derivatives of the primitive gut




































Pharyngeal gut Pharynx and related glands
Foregut Oesophagus
Trachea and lung buds
Stomach
Duodenum proximal to the entrance
of the bile duct
Liver, biliary apparatus and pancreas
Midgut Duodenum distal to the opening of the bile duct
Small intestine
Caecum and appendix
Ascending colon and two-thirds of the transverse colon
Hindgut Distal third of the transverse colon, descending colon and sigmoid colon
Rectum and the superior part of the anal canal
Epithelium of the urinary bladder and most of the urethra


Table 13.2 Contributions of germ layers in development of the gut
























Germ layer Derived components
Endoderm Epithelium of the digestive system
Parenchyma of the derivates of the gut
Splanchnic mesoderm Connective tissue
Muscular components
Peritoneal components
Ectoderm Distal part of the anal canal


Table 13.3 Arterial supply of the primitive gut


















Portion of primitive gut Arterial supply
Foregut Branches of the coeliac trunk
Midgut Branches of the superior mesenteric artery
Hindgut Branches of the inferior mesenteric artery


Foregut



Development of the oesophagus


In week 4, a respiratory diverticulum (lung bud) appears in the ventral wall of the foregut just beneath the pharyngeal gut. This diverticulum gradually gets partitioned from the dorsal part of the foregut by the tracheoesophageal septum. Thus, the foregut divides into a ventral respiratory primordium and a dorsal oesophagus. The oesophagus rapidly lengthens as the heart and lungs descend. The characteristics of the muscle coat of the oesophagus are outlined in Table 13.4.



Table 13.4 Characteristics of the oesophageal muscle coat



















Portion of oesophagus Muscle type Nerve supply
Upper two-thirds Striated Vagus nerve
Lower
third
Smooth Splanchnic plexus


Development of the stomach


The stomach appears as a fusiform dilation of the foregut during week 4. It subsequently rotates around a longitudinal and an anteroposterior axis (Figure 13.2). The effects of this rotation have been summarised in Table 13.5.



Figure 13.2

Schematic representation of the rotation of the stomach on its anteroposterior axis



Table 13.5 Rotational changes during development of the stomach



















Rotational change Effects
90°clockwise rotation around its longitudinal axis The original left side now faces anterior and the original right side faces posterior
The left vagus nerve consequently innervates the anterior wall and the right innervates the posterior wall
Anteroposterior rotation The cephalic and caudal ends of the stomach no longer lie in the midline
The caudal or pyloric part moves to the right and upward and the cephalic or cardiac portion moves to the left and slightly downward

During rotation, the original posterior wall (now on the left) grows faster than the anterior portion (now on the right), forming the greater and lesser curvatures respectively. The stomach thus assumes its final position, its axis running from above left to below right.



Mesenteries of the stomach


The stomach is suspended from the dorsal wall and ventral body wall by mesenteries, known as the dorsal and ventral mesogastrium respectively. Its rotation and dispro-portionate growth alter the position of these mesenteries.


The dorsal mesogastrium is pulled to the left, creating a space behind the stomach called the omental bursa (lesser peritoneal sac). It continues to grow down, forming a double-layered sac – the greater omentum (Figure 13.3). The two leaves of the greater omentum later fuse with each other and with the mesentery of the transverse colon.



Figure 13.3

The formation of the omental bursa and the greater omentum


The ventral mesogastrium is pulled to the right, forming the lesser omentum (which passes from the liver to the lesser curvature of the stomach) and the falciform ligament (which extends from the liver to the ventral abdominal wall). On its way from the umbilical cord to the liver, the umbilical vein passes in the free border of the falciform ligament (Figure 13.4).



Figure 13.4

The effect of rotation of the stomach on the position of the mesenteries



Development of the duodenum


The duodenum also develops early in week 4. Since it develops from both the terminal part of the foregut and the proximal part of the midgut, it is supplied by branches of both the coeliac artery and the superior mesenteric artery. The junction of these two parts is just distal to the origin of the bile duct. As the stomach rotates, the duodenum takes on the form of a C-shaped loop, rotates to the right and becomes retroperitoneal. The region of the duodenal cap, however, retains its mesentery and remains intraperitoneal. During weeks 5–6, proliferation of epithelial cells results in temporary obliteration of the lumen of the duodenum, but this is recanalised by the end of the embryonic period.



Development of the liver and biliary apparatus


Rapidly proliferating cells at the distal end of the foregut result in the formation of a ventral outgrowth early in week 4. This is the hepatic diverticulum (liver bud), which then penetrates the septum transversum and goes on to form the liver and the biliary apparatus (Figure 13.5). The bile duct is formed when the connection between the hepatic diverticulum and the foregut (duodenum) subsequently narrows. The bile duct develops a small ventral outgrowth that then goes on to form the gallbladder and the cystic duct.



Figure 13.5

Sagittal sections showing the penetration of the septum transversum by the rapidly proliferating cells of the hepatic diverticulum (liver bud) and the subsequent development of the liver and the biliary apparatus


The surface mesoderm of the liver differentiates into visceral peritoneum, except on the cranial surface, where the liver remains in contact with the rest of the original septum transversum. This portion of the septum, which comprises densely packed mesoderm, forms the central tendon of the diaphragm, and the surface of the liver that is in contact with the future diaphragm forms the bare area of the liver. This area is never covered by peritoneum. The liver grows rapidly and, by week 9, accounts for approximately 10% of the body weight. Initially, the right and left lobes are approximately the same size, but the right lobe soon becomes larger.


Haematopoiesis begins during week 6, giving the liver a bright red appearance. Bile formation by hepatic cells begins during week 12. When the cystic duct joins the hepatic duct to form the bile duct, bile enters the gastro-intestinal tract and its contents take on a dark green colour. This entrance of the bile duct is initially anterior but, because of positional changes of the duodenum, it moves posteriorly and finally comes to lie behind the duodenum. The origin of various hepatic cells is outlined in Table 13.6.



Table 13.6 Origin of hepatic cells and sinusoids






















Origin Cell type
Mesoderm of the septum transversum Haematopoetic cells
Kupffer cells
Connective tissue cells
Liver cords Parenchyma (liver cells) lining the biliary ducts
Intermingling of epithelial liver cords with vitelline and umbilical veins Hepatic sinusoids


Development of the pancreas


Two separate buds, the ventral and dorsal pancreatic buds, originate from the endodermal lining of the duodenum and grow rapidly between the layers of the dorsal mesentery. These go on to form the pancreas (Figure 13.6). The larger dorsal pancreatic bud appears first and develops cranial to the ventral pancreatic bud, which in turn develops near the entry of the bile duct into the duodenum. Rotation of the duodenum causes the ventral bud to move dorsally and finally to lie immediately below and behind the dorsal bud. Subsequently, the parenchyma and the duct systems of the two buds fuse and the main pancreatic duct enters the duodenum along with the bile duct at the major papilla. The accessory pancreatic duct (when present) enters the duodenum at the minor papilla. Figure 13.6 and Table 13.7 provide more details.



Figure 13.6

Development of the pancreas



Figure 13.7

Partitioning of the cloaca



Table 13.7 Origin of parenchyma and duct system of the pancreas





















Origin Final structure
Ventral pancreatic bud Uncinate process and inferior part of head of pancreas
Dorsal pancreatic bud Entire pancreas except for the above
Ventral pancreatic duct and the distal part of dorsal pancreatic duct Main pancreatic duct (of Wirsung)
Proximal part of dorsal pancreatic duct (if and when it persists) Accessory pancreatic duct (of Santorini)

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jan 29, 2017 | Posted by in GYNECOLOGY | Comments Off on Development and congenital anomalies of the gastrointestinal tract

Full access? Get Clinical Tree

Get Clinical Tree app for offline access