Defects of Thyroxine-Binding Globulin

Chapter 558 Defects of Thyroxine-Binding Globulin

Stephen LaFranchi

Abnormalities in levels of thyroxine-binding globulin (TBG) are not associated with clinical disease and do not require treatment. They are usually uncovered by a chance finding of abnormally low or high levels of thyroxine (T₄) and may be a source of confusion in the diagnosis of hypothyroidism or hyperthyroidism.

TBG deficiency occurs as an X-linked dominant disorder. Congenital TBG deficiency is most often discovered through screening programs for neonatal hypothyroidism that use levels of T₄ as the primary screen. Affected patients have low levels of T₄ and elevated resin triiodothyronine uptake (RT₃U), but levels of free T₄

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Tags: Nelson Textbook of Pediatrics Expert Consult

Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off

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