Cystic Lung Mass
Paula J. Woodward, MD
DIFFERENTIAL DIAGNOSIS
Common
Congenital Diaphragmatic Hernia
Congenital Cystic Adenomatoid Malformation, Macrocystic
Less Common
Lymphangioma
Bronchogenic Cyst
Neurenteric Cyst
ESSENTIAL INFORMATION
Key Differential Diagnosis Issues
Where is the stomach?
If it is below the diaphragm, a congenital diaphragmatic hernia (CDH) is less likely
CDH without gastric herniation (small bowel, liver) generally appears as solid or echogenic mass
Simple cyst vs. complex cystic mass
Bronchogenic cyst and neurenteric cyst more likely to be single simple cysts
CDH, macrocystic congenital cystic adenomatoid malformation (CCAM), and lymphangioma are generally large complex masses
Does the mass extend beyond the chest wall?
Lymphangioma has bulk of mass in subcutaneous tissues, not in chest cavity
Always evaluate spine
Neurenteric cysts often associated with thoracic boney abnormality
Helpful Clues for Common Diagnoses
Congenital Diaphragmatic Hernia
Left-sided hernias most common (80-90%)
Stomach causes cystic mass in chest
Four classic findings of left-sided hernia
Cystic mass in left side of chest
Absence of fluid-filled stomach in abdomen
Deviation of heart toward right
Polyhydramnios
Small bowel and liver are often also herniated but harder to see
Very important to determine contents of hernia
Those with “liver up” have poorer prognosis
Abdominal circumference less than expected
Most hernias are posterior through foramen of Bochdalek
Must evaluate diaphragm in sagittal plane
Anterior coronal plane can completely miss diaphragmatic defect
Look carefully for other anomalies including chromosomal
Up to 50% will have an associate abnormality
Color Doppler helpful to look for portal/hepatic veins in herniated liver
Even with Doppler, it may be difficult to see liver if only a small portion of the left lobe is herniated
MR extremely valuable for determining contents of hernia
Meconium-filled bowel is bright on T1WI
Fluid-filled bowel is bright on T2WI
Liver is dark on T2WI
Normal lung intermediate signal on T2WI
Congenital Cystic Adenomatoid Malformation, Macrocystic
Lung hamartoma with proliferation of terminal bronchioles and lack of normal alveoli
Morphology varies from solid appearing (microcystic) to complex cystic mass (macrocystic) or even unilocular
Macrocystic congenital cystic adenomatoid malformation (CCAM)
1 or more cysts > 5 mm
Often multiple cysts of varying sizes
May have single large cyst
Borders poorly defined
Both arterial supply and venous drainage from pulmonary circulation
Stomach is below diaphragm
Abdominal circumference is normal
95% unilateral and affect only 1 lobe
No predilection for side (R = L)
Helpful Clues for Less Common Diagnoses
Lymphangioma
Complex cystic body wall mass
Sonolucent cysts
Septa of variable thicknesses
No solid components
May enlarge during pregnancy
Associated anomalies rare
Mediastinal involvement common but bulk of the mass will be outside thoracic cavity
Can be located anywhere in soft tissues
70% are axillary
30% involve trunk or limbs
Axillary masses typically between arm and chest wall
Arm held away from fetal trunk
May extend down arm
Secondary lymphedema common
Rib deformity common
Associated pleural effusion rare
Bronchogenic Cyst
Smooth, unilocular cyst
Most commonly mediastinal but may be in lung parenchyma
Mediastinal cysts
Majority in middle mediastinum typically paratracheal, carinal, or hilar
Pulmonary
Majority in medial third of lungs
More frequent in lower lobes
Equal incidence in both lungs (R = L)
Neurenteric Cyst
Single, smooth, unilocular cyst
Round to dumbbell shape
Dumbbell shape suggests extension into spinal canal
Located midline by spine
Thoracic spine most common site, followed by cervical spine
Vertebral anomalies (both segmentation and fusion) in up to 50%
Butterfly vertebrae
Hemivertebrae
Vertebral clefts
Diastematomyelia
Etiology thought to be incomplete separation of notochord layer from endoderm (primitive foregut)
Small piece of primitive gut becomes trapped in developing spinal canalStay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree