Concomitant Bacterial Infection in Infants with Respiratory Syncytial Virus
Juliana Mariani
Chadi M. El Saleeby
Risk of Serious Bacterial Infection in Young Febrile Infants With Respiratory Syncytial Virus Infections
Levine DA, Platt SL, Dayan PS, et al. Pediatrics. 2004;113(6):1728–1734
Background
Febrile infants ≤60 days old are at high risk for serious bacterial infections (SBIs), including meningitis, bacteremia, and urinary tract infections (UTIs). It was unclear whether young infants with documented respiratory syncytial virus (RSV) infection also had a similarly elevated risk.
Objectives
To assess the risk of SBIs in febrile infants with RSV as compared to those without RSV.
Methods
Prospective cross-sectional study in 8 US centers from 1998 to 2001.
Patients
1,248 febrile (≥38°C) infants ≤60 days old presenting to a pediatric emergency department. Select exclusion criteria: antibiotics ≤48 hours prior to presentation, no bacterial cultures or RSV testing obtained.
Intervention
Patients underwent history and physical examination, nasopharyngeal swab for RSV rapid antigen detection, complete blood count with differential and cultures of blood, urine, and cerebrospinal fluid (CSF).
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