Each central line-associated bloodstream infection (CLABSI) in a child prolongs hospitalization by an average of 19 days, and adds approximately $56,000 to the costs of care.¹ Standardized care bundles can reduce CLABSI incidence in adult patients by about 66%; most of that improvement comes from safer line-insertion practices.² Since children have fewer central venous catheters (CVCs) placed, a greater proportion of their infection risk occurs during line maintenance. An initial pediatric study demonstrated a nearly 50% reduction in CLABSIs over 1 year using insertion and maintenance care bundles.³ This follow-up study evaluated the sustainability of those improvements.