• Diagnostic: Sampling of fluid for laboratory evaluation (eg, septic joint, inflammatory arthritis).
• Therapeutic.
• Injection of corticosteroids.
• Injection of local anesthetic.
• Removal of hemarthrosis for pain relief following trauma.
• Skin or soft tissue infection (eg, cellulitis, septic bursitis) because there is an increased risk of causing a septic joint.
• Corticosteroid injection into a known or suspected septic joint.
• Coagulopathy. The procedure may result in hemarthrosis, but one needs to weigh the risk against the need to diagnose a septic joint.
• Bacteremia, because of the increased risk of causing septic joint.
• Syringes (20 mL for knee; 10 mL for ankle).
• 21–25-gauge needles; they must be long enough to enter joint.
• Sterile collection container.
• Povidone-iodine and alcohol for sterile preparation of skin.
• Sterile gloves.
• 4 × 4 gauze.
• Ethyl chloride (optional).
• Lidocaine (optional).
• Infection occurs in < 1/10,000 when performed under sterile conditions.
• Bleeding into joint is exceedingly rare, even in patients who are taking anticoagulant medication.
• If corticosteroids are being injected, there is a risk of skin discoloration and fat atrophy following the procedure.
• Do not make an ink mark directly over injection/aspiration site because it will enter the joint when the needle passes through it.
• Instead, use the wood end of a sterile cotton swab or another round object to make an indentation in the skin prior to cleaning with povidone-iodine.
• If infection is a concern, a larger bore needle (18 gauge or 19 gauge) may be needed to aspirate because sometimes purulent fluid will not be drawn into a smaller needle.
• Do not overtighten the needle on to the syringe, and check to make sure the needle easily twists off the syringe before starting the procedure.
• This allows you to empty a full syringe and reattach it without ever pulling the needle out of the joint.
• Lidocaine can be used to numb the skin prior to aspiration/injection, but it can distort anatomic landmarks.
• Alternatively, a topical agent such as ethyl chloride can be used.