Chapter 479 Anatomy and Function of the Spleen Amanda M. Brandow, Bruce M. Camitta Anatomy The splenic precursor is recognizable by 5 wk of gestation. At birth, the spleen weighs approximately 11 g. Thereafter, it enlarges until puberty, reaching an average weight of 135 g, and then diminishes in size during adulthood. Approximately 15% of patients will have an accessory spleen. The major splenic components are a lymphoid compartment (white pulp) and a filtering system (red pulp). The white pulp consists of periarterial lymphatic sheaths of T lymphocytes with embedded germinal centers containing B lymphocytes. The red pulp has a skeleton of fixed reticular cells, mobile macrophages, partially collapsed endothelial passages (cords of Billroth), and splenic sinuses. A marginal zone rich in dendritic (antigen-presenting) cells separates the red pulp from the white pulp. The splenic capsule contains smooth muscle and contracts in response to epinephrine. Approximately 10% of the blood delivered to the spleen flows rapidly through a closed vascular network. The other 90% flows more slowly through an open system (the splenic cords), where it is filtered through 1-5 µm slits before entering the splenic sinuses. Function Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Rumination, Pica, and Elimination (Enuresis, Encopresis) Disorders Adolescent Pregnancy Neisseria gonorrhoeae (Gonococcus) Blastomycosis (Blastomyces dermatitidis) Stay updated, free articles. Join our Telegram channel Join Tags: Nelson Textbook of Pediatrics Expert Consult Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off on Anatomy and Function of the Spleen Full access? Get Clinical Tree
Chapter 479 Anatomy and Function of the Spleen Amanda M. Brandow, Bruce M. Camitta Anatomy The splenic precursor is recognizable by 5 wk of gestation. At birth, the spleen weighs approximately 11 g. Thereafter, it enlarges until puberty, reaching an average weight of 135 g, and then diminishes in size during adulthood. Approximately 15% of patients will have an accessory spleen. The major splenic components are a lymphoid compartment (white pulp) and a filtering system (red pulp). The white pulp consists of periarterial lymphatic sheaths of T lymphocytes with embedded germinal centers containing B lymphocytes. The red pulp has a skeleton of fixed reticular cells, mobile macrophages, partially collapsed endothelial passages (cords of Billroth), and splenic sinuses. A marginal zone rich in dendritic (antigen-presenting) cells separates the red pulp from the white pulp. The splenic capsule contains smooth muscle and contracts in response to epinephrine. Approximately 10% of the blood delivered to the spleen flows rapidly through a closed vascular network. The other 90% flows more slowly through an open system (the splenic cords), where it is filtered through 1-5 µm slits before entering the splenic sinuses. Function Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Rumination, Pica, and Elimination (Enuresis, Encopresis) Disorders Adolescent Pregnancy Neisseria gonorrhoeae (Gonococcus) Blastomycosis (Blastomyces dermatitidis) Stay updated, free articles. Join our Telegram channel Join Tags: Nelson Textbook of Pediatrics Expert Consult Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off on Anatomy and Function of the Spleen Full access? Get Clinical Tree
