Air-Containing Lesions in Neck
Bernadette L. Koch, MD
DIFFERENTIAL DIAGNOSIS
Common
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General Trauma
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Retropharyngeal Space (RPS) Abscess
Less Common
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Laryngocele
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Esophago-Pharyngeal Diverticulum
Rare but Important
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4th Branchial Anomaly
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Lateral Cervical Esophageal Diverticulum
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Spontaneous Cervical Emphysema
ESSENTIAL INFORMATION
Helpful Clues for Common Diagnoses
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General Trauma
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Key facts: Esophageal, pharyngeal, laryngeal, or superficial trauma
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Imaging: Extraluminal air in neck ± laryngeal, hyoid, or facial fractures
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Retropharyngeal Space (RPS) Abscess
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Key facts: Posterior to pharyngeal mucosal space, anterior to prevertebral space
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Imaging: Extranodal purulent fluid in RPS ± air in or adjacent to fluid collection ± extension to mediastinum
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Helpful Clues for Less Common Diagnoses
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Laryngocele
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Key facts: Lateral saccular cyst, laryngeal mucocele
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Imaging: Air ± air-filled level
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Internal laryngocele in paraglottic space
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Mixed laryngocele in paraglottic and submandibular spaces
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Esophago-Pharyngeal Diverticulum
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Key facts: Zenker diverticulum = mucosal-lined outpouching of posterior hypopharynx
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Imaging: Air-filled pouch posterior; usually extends left of esophagus
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Helpful Clues for Rare Diagnoses
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4th Branchial Anomaly
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Key facts: 4th pharyngeal pouch remnant
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Extends from apex of pyriform sinus to lower neck, anterior to left thyroid lobe
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Present with recurrent thyroiditis or anterior neck abscess
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Imaging
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Abscess anterior to left thyroid lobe ± intrinsic inflammatory change in ipsilateral thyroid lobe
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Inflamed pyriform sinus apex
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Lack of aeration of pyriform sinus apex
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Lateral Cervical Esophageal Diverticulum
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Key facts: Mucosal-lined outpouching lateral to cervical esophagus
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Imaging: Air-filled pouch lateral to cervical esophagus
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Spontaneous Cervical Emphysema
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Key facts: No history of vomiting, trauma, asthma, or other inciting event
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Imaging: Pneumomediastinum and cervical emphysema
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Image Gallery
![]() Axial CECT shows extensive air nearly surrounding the larynx
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