Adolescent Hypertension



Adolescent Hypertension


Stephen R. Daniels



Hypertension is a major risk factor for cardiovascular disease in adults. It has been clearly shown in the Framingham Study and other epidemiologic studies that higher levels of systolic and diastolic blood pressure are associated with increased risk of cerebrovascular accidents, myocardial infarction, congestive heart failure, and renal failure.

Blood pressure elevation is also important in adolescents. It has been shown that adolescents with blood pressure elevation are more likely to become adults with hypertension. This phenomenon is often referred to as blood pressure tracking.

Elevated blood pressure in adolescence has been associated with early cardiovascular abnormalities. For example, the Pathobiological Determinants of Atherosclerosis in Youth (PDAY). Study evaluated the effects of nonlipid risk factors on the presence of atherosclerotic lesions in young persons who had died of accidental causes. These investigators found that among persons with normal cholesterol levels, black study subjects with hypertension had more raised lesions in the coronary arteries than black subjects without hypertension. In the Bogalusa Heart Study, the level of blood pressure was associated with the extent of fatty streaks and fibrous plaques in the aorta and coronary arteries. Left ventricular hypertrophy has also been found to be prevalent in children and adolescents with essential hypertension. In one study, 14% of adolescents with hypertension had left ventricular mass index greater than the ninety-ninth percentile for age.

Blood pressure elevation in adolescents is associated with increased risk of adverse effects in the heart and blood vessels. These adverse effects appear to be magnified when hypertension is accompanied by other risk factors such as obesity, dyslipidemia, diabetes mellitus, and cigarette smoking.

Hypertension may also be a presenting feature of important illness. Renal disease, trauma, increased intracranial pressure, and some pharmacologic agents may be associated with blood pressure elevation.


EPIDEMIOLOGY: PREVALENCE OF HYPERTENSION

On an initial measurement of blood pressure, approximately 5% of adolescents will have blood pressure elevation. However, with repeat blood pressure measurements, the prevalence of hypertension is only approximately 2%. The prevalence of primary and secondary forms of hypertension has been somewhat controversial. Although secondary forms of hypertension may be more common in infants and children, in adolescents the prevalence of primary hypertension is probably similar to the 95% prevalence seen in adults. In general, the younger the patient, the higher the blood pressure, and with less family history of hypertension, secondary forms of hypertension are more likely. The common causes of secondary hypertension in adolescents are presented in Box 93.1.


DIAGNOSIS


Blood Pressure Measurement

To recognize hypertension, it is important to measure blood pressure correctly. The National High Blood Pressure Education Program recommends auscultation as the standard approach. However, concerns about mercury toxicity have led some hospitals and clinics to remove mercury column sphygmomanometers and institute use of automated devices. Most automated devices use oscillometric methodology. It is important to review data on validation and reliability before accepting a device for use. Another alternative for blood pressure measurement is to use an aneroid device. However, these devices must be periodically calibrated against a mercury column.

No matter which equipment is used, the selection of an appropriately sized cuff is one of the most important aspects of blood pressure measurement. The recommended approach is to use a cuff with a bladder width that is approximately 40% of the upper arm circumference between the acromion and the olecranon. The length of the cuff bladder should include 80% to 100% of the arm circumference. Manufacturers of cuffs usually have lines on the cuff that indicate the range of arm sizes for which that cuff bladder will be appropriate.

Blood pressure should usually be measured in the right arm with the patient in the sitting position after a period of 3 to 5 minutes of rest. The arm in which the blood pressure is measured should be resting at heart level on a solid surface. The cuff should be inflated approximately 20 mm Hg above the
point at which the radial pulse disappears. The cuff is deflated at a rate of 2 to 3 mm Hg per second. The first Korotkoff phase (appearance of snapping tones) is used to indicate systolic pressure, and the fifth Korotkoff phase (disappearance of sound) is used to determine the diastolic blood pressure.



Assessment of Blood Pressure

In adults, blood pressure standards are based on the relationship to outcomes. In adolescents, there are no outcome-based standards. Instead, a “distributational” approach is used. In this classification approach, blood pressure percentiles based on the patient’s age, sex, and height are used. Blood pressure lower than the ninetieth percentile is considered normal. Systolic or diastolic blood pressure between the ninetieth and ninety-fifth percentiles is considered to be prehypertension. As with adults, adolescents with blood pressure 120/80 mm Hg or higher should also be considered prehypertensive. Blood pressure above the ninety-fifth percentile that remains above the ninety-fifth percentile on three separate occasions is considered to be in the hypertensive range. Those in the hypertensive range should be classified as having either stage 1 or stage 2 hypertension. These cutpoints are presented in Table 93.1. Stage 2 hypertension is when the blood pressure is higher than 5 mm Hg above the ninety-ninth percentile. Stage 2 hypertension often requires immediate evaluation and treatment. The blood pressure percentiles recommended by the National High Blood Pressure Education Program are present in Tables 93.2 and 93.3.








TABLE 93.1. CLASSIFICATION OF BLOOD PRESSURE IN CHILDREN AND ADOLESCENTS























Blood Pressure Level Based on Percentile Classification
<90th percentile Normal blood pressure
90th–95th percentile High normal or borderline blood pressure elevation
>95th percentile High blood pressure
>95th percentile persistent on at least three separate occasions Hypertension
95th–99th percentile + 5 mm Hg Stage 1 hypertension
>99th percentile + 5 mm Hg Stage 2 hypertension


Clinical Evaluation of Hypertension

Adolescents with suspected hypertension should have a complete history and physical examination. The history and examination may yield clues to whether a secondary form of hypertension is present. For example, a history of abdominal pain, dysuria, frequency, nocturia, and enuresis may suggest the presence of underlying renal disease. The absence of femoral pulses may indicate coarctation of the aorta.

Primary hypertension is rarely accompanied by abnormalities in the history of present illness or the physical examination. Symptoms such as headache, visual disturbance, chest pain, and epistaxis are often attributed to blood pressure elevation, but in fact these features are rarely associated with mild to moderate blood pressure elevation. Adolescent patients with primary hypertension often have a positive family history of hypertension and are more likely to be overweight.


Laboratory Evaluation

The standard approach to laboratory testing at the initial evaluation of adolescents with hypertension includes the urinalysis, blood urea nitrogen, creatinine, electrolytes, and complete blood count. Because cardiovascular risk factors may cluster in patients, particularly when obesity and the metabolic syndrome are present, it is useful to assess the fasting lipid profile. Abnormalities in the history and physical examination may suggest additional laboratory tests to evaluate the possibility of secondary hypertension. Finally, with persistent blood pressure elevation, a renal ultrasound study may provide important information about structural abnormalities of the urinary tract.


Consideration of White Coat Hypertension

Some adolescent patients may have blood pressure elevation only in the physician’s office or under other stressful conditions. This is often referred to as white coat hypertension. Assessment of possible white coat hypertension can be accomplished by home blood pressure measurement or with 24-hour ambulatory blood pressure monitoring. When home blood pressure measurements are normal or when ambulatory monitoring reveals less than 20% of blood pressures above the ninety-fifth percentile, then the diagnosis of white coat hypertension should be entertained. Conversely, it is not clear that patients with white coat hypertension should be considered to have normal blood pressure. There is evidence to


suggest that these patients are at risk for future, persistent hypertension.








TABLE 93.2. BP LEVELS FOR BOYS BY AGE AND HEIGHT PERCENTILE







































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































Age, y BP Percentile SBP, mm Hg
Percentile of Height
DBP, mm Hg
Percentile of Height
5th 10th 25th 50th 75th 90th 95th 5th 10th 25th 50th 75th 90th 95th
1 50th 80 81 83 85 87 88 89 34 35 36 37 38 39 39
90th 94 95 97 99 100 102 103 49 50 51 52 53 53 54
95th 98 99 101 103 104 106 106 54 54 55 56 57 58 58
99th 105 106 108 110 112 113 114 61 62 63 64 65 66 66
2 50th 84 85 87 88 90 92 92 39 40 41 42 43 44 44
90th 97 99 100 102 104 105 106 54 55 56 57 58 58 59
95th 101 102 104 106 108 109 110 59 59 60 61 62 63 63
99th 109 110 111 113 115 117 117 66 67 68 69 70 71 71
3 50th 86 87 89 91 93 94 95 44 44 45 46 47 48 48
90th 100 101 103 105 107 108 109 59 59 60 61 62 63 63
95th 104 105 107 109 110 112 113 63 63 64 65 66 67 67
99th 111 112 114 116 118 119 120 71 71 72 73 74 75 75
4 50th 88 89 91 93 95 96 97 47 48 49 50 51 51 52
90th 102 103 105 107 109 110 111 62 63 64 65 66 66 67
95th 106 107 109 111 112 114 115 66 67 68 69 70 71 71
99th 113 114 116 118 120 121 122 74 75 76 77 78 78 79
5 50th 90 91 93 95 96 98 98 50 51 52 53 54 55 55
90th 104 105 106 108 110 111 112 65 66 67 68 69 69 70
95th 108 109 110 112 114 115 116 69 70 71 72 73 74 74
99th 115 116 118 120 121 123 123 77 78 79 80 81 81 82
6 50th 91 92 94 96 98 99 100 53 53 54 55 56 57 57
90th 105 106 108 110 111 113 113 68 68 69 70 71 72 72
95th 109 110 112 114 115 117 117 72 72 73 74 75 76 76
99th 116 117 119 121 123 124 125 80 80 81 82 83 84 84
7 50th 92 94 95 97 99 100 101 55 55 56 57 58 59 59
90th 106 107 109 111 113 114 115 70 70 71 72 73 74 74
95th 110 111 113 115 117 118 119 74 74 75 76 77 78 78
99th 117 118 120 122 124 125 126 82 82 83 84 85 86 86
8 50th 94 95 97 99 100 102 102 56 57 58 59 60 60 61
90th 107 109 110 112 114 115 116 71 72 72 73 74 75 76
95th 111 112 114 116 118 119 120 75 76 77 78 79 79 80
99th 119 120 122 123 125 127 127 83 84 85 86 87 87 88
9 50th 95 96 98 100 102 103 104 57 58 59 60 61 61 62
90th 109 110 112 114 115 117 118 72 73 74 75 76 76 77
95th 113 114 116 118 119 121 121 76 77 78 79 80 81 81
99th 120 121 123 125 127 128 129 84 85 86 87 88 88 89
10 50th 97 98 100 102 103 105 106 58 59 60 61 61 62 63
90th 111 112 114 115 117 119 119 73 73 74 75 76 77 78
95th 115 116 117 119 121 122 123 77 78 79 80 81 81 82
99th 122 123 125 127 128 130 130 85 86 86 88 88 89 90
11 50th 99 100 102 104 105 107 107 59 59 60 61 62 63 63
90th 113 114 115 117 119 120 121 74 74 75 76 77 78 78
98th 117 118 119 121 123 124 125 78 78 79 80 81 82 82
99th 124 125 127 129 130 132 132 86 86 87 88 89 90 90
12 50th 101 102 104 106 108 109 110 59 60 61 62 63 63 64
90th 115 116 118 120 121 123 123 74 75 75 76 77 78 79
98th 119 120 122 123 125 127 127 78 79 80 81 82 82 83
99th 126 127 129 131 133 134 135 86 87 88 89 90 90 91
13 50th 104 105 106 108 110 111 112 60 60 61 62 63 64 64
90th 117 118 120 122 124 125 126 75 75 76 77 78 79 79
98th 121 122 124 126 128 129 130 79 79 80 81 82 83 83
99th 128 130 131 133 135 136 137 87 87 88 89 90 91 91
14 50th 106 107 109 111 113 114 115 60 61 62 63 64 65 65
90th 120 121 123 125 126 128 128 75 76 77 78 79 79 80
98th 124 125 127 128 130 132 132 80 80 81 82 83 84 84
99th 131 132 134 136 138 139 140 87 88 89 90 91 92 92
15 50th 109 110 112 113 115 117 117 61 62 63 64 65 66 66
90th 122 124 125 127 129 130 131 76 77 78 79 80 80 81
98th 126 127 129 131 133 134 135 81 81 82 83 84 85 85
99th 134 135 136 138 140 142 142 88 89 90 91 92 93 93
16 50th 111 112 114 116 118 119 120 63 63 64 65 66 67 67
90th 125 126 128 130 131 133 134 78 78 79 80 81 82 82
98th 129 130 132 134 135 137 137 82 83 83 84 85 86 87
99th 136 137 139 141 143 144 145 90 90 91 92 93 94 94
17 50th 114 115 116 118 120 121 122 65 66 66 67 68 69 70
90th 127 128 130 132 134 135 136 80 80 81 82 83 84 84
98th 131 132 134 136 138 139 140 84 85 86 87 87 88 89
99th 139 140 141 143 145 146 147 92 93 93 94 95 96 97

Only gold members can continue reading. Log In or Register to continue

Stay updated, free articles. Join our Telegram channel

Jul 24, 2016 | Posted by in PEDIATRICS | Comments Off on Adolescent Hypertension

Full access? Get Clinical Tree

Get Clinical Tree app for offline access