A peculiar site




Case notes


In February 2011, a 67-year-old multiparous woman with a 2-month history of postmenopausal bleeding was admitted to a local hospital, where a cervical biopsy was performed. Histopathologic examination of the tissue sample indicated a cervical malignant melanoma. She was then referred to our institution.


Examination of the head, eyes, ears, nose, and throat revealed a 4 × 2.5–cm yellow papillary mass on the right tonsil. On biopsy, the growth proved to be a pleomorphic adenoma. A gynecologic examination of the atrophic cervix disclosed a 3 × 2.5–cm pigmented papillary mass that was black in color ( Figure 1 ) . A Papanicolaou smear showed round cells with enlarged hyperchromatic nuclei; pigment granules were also seen in some cells ( Figures 2 and 3 ) . The vagina and parametrium were not involved; the uterus was atrophic, mobile, and free of any adnexal mass. No abnormal skin lesions were detected elsewhere on the patient’s body. A chest x-ray and a computed tomography scan of the abdomen and pelvis were negative for metastasis.




FIGURE 1


A black pigmented papillary mass was located on the posterior lip of the patient’s cervix.

Zhang. Melanoma of the cervix. Am J Obstet Gynecol 2011.



FIGURE 2


A Papanicolaou smear shows round cells with large hyperchromatic nuclei in a hemorrhagic background. Pigment granules were also seen. (Hematoxylin and eosin stain; original magnification, ×200.)

Zhang. Melanoma of the cervix. Am J Obstet Gynecol 2011.



FIGURE 3


The Papanicolaou smear, shown at higher power, contained bizarre tumor cells with large hyperchromatic nuclei. (Hematoxylin and eosin stain; original magnification, ×400.)

Zhang. Melanoma of the cervix. Am J Obstet Gynecol 2011.




Conclusions


The diagnosis was stage IB1cervical malignant melanoma, according to the International Federation of Gynecology and Obstetrics classification system for cervical cancer. Radical hysterectomy, bilateral salpingo-oophorectomy, partial vaginectomy, and pelvic lymphadenectomy (PLA) were performed. The tumor was on the posterior lip of the cervix and extended into the endocervical canal, with a 1-cm depth of invasion ( Figure 4 ) . Histologic examination confirmed the diagnosis ( Figures 5 and 6 ) . The surgical margins and the lymph nodes were tumor free. No chemotherapy or radiotherapy was given in the postoperative period.


Jun 4, 2017 | Posted by in GYNECOLOGY | Comments Off on A peculiar site

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