15 – Anaphylaxis in Labour




15 Anaphylaxis in Labour


Andrew Parkes and Shuayb Elkhalifa



Scenario in a Nutshell



Severe life-threatening anaphylaxis following benzypenicillin IV for intrapartum antibiotic prophylaxis for group B streptococcal colonisation.


Stage 1: Recognition of anaphylaxis and initial management.


Stage 2: Patient continues to deteriorate, with airway, respiratory and cardiovascular compromise.


Stage 3: Continuing severe life-threatening anaphylaxis.


Stage 4: Patient continues to deteriorate, requiring intubation, ventilation and referral to critical care.



Target Learner Groups


All members of the multidisciplinary obstetric team: midwives, obstetricians, anaesthetists.

















Specific learning opportunities
Knowledge of common causes of anaphylaxis
Recognition of anaphylaxis
Knowledge of algorithm for treatment of severe life-threatening anaphylaxis
Orientation – knowledge of emergency equipment to treat anaphylaxis in local environment








































Suggested learners (to represent their normal roles) In the room from the start Available when requested
Anaesthetic CT2
Anaesthetic ST3+
Obstetric ST3+
Midwife Coordinator
Suggested facilitators
Midwife √ (first to respond)
Faculty to play role of partner


Details for Facilitators



Patient Demographics









Name: Kira


Age: 38


Gestation: 37


Booking weight: 87 kg


Parity: P3 (Prev NVD)



Scenario Summary for Facilitators



38-year-old para 3, 37 weeks pregnant, admitted to delivery suite in active labour. Spontaneous rupture of membranes (SROM) 2 hours ago, examined 1 hour ago, cervix 4 cm dilated. Receiving first dose of antibiotics for group B Streptococcus.


Previous baby with group B streptococcal infection as neonate. Baby spent prolonged period on NICU and parents very anxious.


Shortly after receiving first dose of IV benzylpenicillin (3 g in 100 ml normal saline running over 1 h as per guidelines) patient complains of feeling unwell – hot, light-headed and difficulty breathing.


Partner (facilitator) alerts staff to the problem. He notices that she appears rather red and flushed.


Treatment of severe life-threatening anaphylaxis ensues, requiring repeated IM/IV adrenaline boluses, bronchodilators and intubation/ventilation and delivery.



Set-up Overview for Facilitators






















Clinical setting


  • On delivery suite in a delivery bed

Patient position


  • Lying semi-recumbent on bed

Initial monitoring in place


  • CTG monitor

Other equipment


  • 20G venflon dorsum hand through which benzylpenicillin infusion is running



  • (3 g in 100 ml normal saline running over 1 h or as per local guideline)

Useful manikin features


  • Abnormal breath sounds (wheeze)



  • Palpable pulses



  • Tongue swelling



  • Intubation



Medical Equipment


For core equipment checklist see Chapter 9.



















Additional equipment specific to scenario



  • Nebuliser




  • Benzylpenicillin in 100 ml saline running through Baxter pump




  • Adrenaline




    • 1:1000



    • 1:10,000




  • Hydrocortisone



  • Chlorphenamine




  • Metaraminol



  • Ephedrine



  • Noradrenaline



  • Drugs for intubation




  • Salbutomol




    • Inhalers, nebulisers, infusion




  • Magnesium



  • Aminophylline



Information Given to the Learners










Patient’s relative approaches passing midwife alerting her to his concerns



  • Time: 21:00



  • Please can you help? My wife doesn’t look very well!



  • From the team midwifery handover you know:



  • Patient is 38 years old, otherwise fit and well. 37 weeks pregnant. G4 P3.



  • SROM 2 hours ago, in active labour, 4 cm dilated at last examination 1 hour ago. Previous neonatal sepsis due to Group B Streptococcus. Commenced on benzylpenicillin as per protocol. No known drug allergies.



Scenario Schedule















Suggested Topics for Debrief Discussion




  • How confident were you managing anaphylaxis in the ward environment?



  • Would you intubate and ventilate this deteriorating patient on the ward or transfer to a safer location?



  • When would you check the tryptase levels?

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Oct 24, 2020 | Posted by in OBSTETRICS | Comments Off on 15 – Anaphylaxis in Labour

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