Transitional Cell (Brenner) Tumor

Chapter 143 Transitional Cell (Brenner) Tumor



INTRODUCTION



Description: A transitional cell (Brenner) tumor is an epithelial tumor that is made up of cells that resemble urothelium and Walthard’s cell nests, intermixed with the ovarian stroma. Most are benign.

Prevalence: One percent to 3% of ovarian tumors.

Predominant Age: 40 to 80, average 50.

Genetics: No genetic pattern.


ETIOLOGY AND PATHOGENESIS



Causes: Unknown. Most are derived from ovarian surface epithelium that undergoes metaplasia to form the typical urothelial-like components.

Risk Factors: None known.


CLINICAL CHARACTERISTICS



Signs and Symptoms



• Asymptomatic (often an incidental finding after oophorectomy)

• Adnexal mass, generally solid, most smaller than 2 cm, bilateral in 6% (unilateral lesions are more common in the left ovary)

• Abdominal pain and swelling, with abnormal uterine bleeding (20%) if malignant disease (malignant masses are more likely to be large [10 to 30 cm] and contain cystic areas; when the ovary is palpably enlarged, the risk of malignancy is approximately 5%)


DIAGNOSTIC APPROACH



Differential Diagnosis



• Thecoma (fibroma)

• Stromal and germ cell tumors

• Endometrioma

• Benign cystic teratoma

• Serous or mucinous cystadenoma

• Metastatic tumors

• Pedunculated leiomyomata


Associated Conditions: Malignant tumors are associated with endometrial hyperplasia.


WORKUP AND EVALUATION


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Jun 6, 2016 | Posted by in GYNECOLOGY | Comments Off on Transitional Cell (Brenner) Tumor

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