Patients who develop either perforation with diffuse peritonitis or obstruction that is unresponsive to medical management are rare but may require an urgent operation. The operative goal in this situation is to control sepsis and decompress the intestine with as little risk to the patient as possible. The peritoneal cavity may be very hostile with inflammatory adhesions, fistulas, friable bowel, and diffuse peritonitis that make any extensive dissection ill advised. Rather than proceed with extensive surgery, often the most prudent approach is to divert the fecal stream with a proximal ostomy [24]. Resection of the involved segment may or may not be possible and occasionally a proximal diversion is necessary without addressing the actual diseased bowel. In other cases the perforated or obstructed segment can be resected but sepsis or lack of bowel integrity makes bowel anastomosis unsafe.

Fortunately, permanent ileostomy is uncommon in the pediatric patient which is important since ileostomies are associated with significant complications at the ileostomy site in addition to the accompanying social stigmata [25]. Once the intra-abdominal sepsis is controlled and the inflammatory adhesions are allowed to resolve for 6–8 weeks following emergent ileostomy, a more definitive procedure with ostomy closure can be considered. Although no one, especially teenagers and their parents want an ileostomy, attempting an extensive dissection or bowel anastomosis in the face of severe inflammation can result in the loss of large segments of small bowel which is more detrimental in the long run.

Similarly, patients with a complete bowel obstruction that does not respond to medical therapy of the Crohn disease require surgical intervention [26]. In patients without evidence of abdominal sepsis or bowel compromise, medical management may allow complete obstruction to resolve and should be attempted prior to surgery. This is especially true in cases involving difficult areas to treat surgically such as the duodenum where avoiding surgical intervention is desirable [27]. If the obstruction fails to resolve or evidence of bowel compromise is present, operation must be undertaken without the ability to prepare the bowel for primary anastomosis. At surgery the bowel is often inflamed and friable and although a definitive resection with re-anastomosis may be possible, the patient and family must be prepared for a temporary diverting ostomy to avoid the risks of a bowel anastomosis. Temporary ileostomy with subsequent closure avoids the risk of an anastomotic leak with potentially devastating complications.

Patients that have had multiple previous abdominal operations may be particularly challenging because of preexisting adhesions and scar tissue. Studies suggest that as many as half of the patients undergoing re-operative surgery will require ileostomy formation [28]. In many pediatric patients this is less of an issue because often patients are making their first trip to the operating room but one should never hesitate to perform a temporary bowel diversion when primary anastomosis may be unsafe.

The indication for surgical intervention is more commonly not emergent and the timing of the intervention requires the careful consideration of the surgeon, the gastroenterologist, and the family. The typical indications for surgery include failure of medical management, stricturing disease with near obstructing lesions, fistulas, and complications related to the side effects of medical therapy.

The preoperative evaluation usually includes both endoscopic and imaging studies. Traditional imaging involves contrast enemas and/or upper gastrointestinal series with small bowel follow through. More recently, magnetic resonance enterography has been utilized to provide a more complete assessment of the entire gastrointestinal tract [29]. These studies offer the advantage of cross-sectional imaging of the entire bowel wall rather than being limited to assessing luminal disease which allows for more accurate surgical planning and facilitates discussions with the patient and family regarding the operative approach. Efforts should be made to control intra-abdominal sepsis through drainage of abscess and treatment with antibiotics prior to surgery along with supporting the nutritional status of the patient. Mechanical bowel preparation has not been shown to be beneficial and, in fact, may increase the rate of infectious complications for all gastrointestinal surgery and is not indicated for surgery on patients with Crohn disease [30].

The presence of a stricture alone is not an indication for operation. Areas of diseased bowel that do not present a mechanical impediment to the flow of the intestinal contents do not require intervention. However, significant chronic obstruction is suggested by dilation of bowel loops proximal to the diseased area (Fig. 37.1). These changes signify a possible impending complete obstruction and elective resection prior to that allows the opportunity for bowel preparation and resection with primary anastomosis rather than a two-stage procedure requiring temporary diversion with subsequent ileostomy closure. Entero-enteral fistulas, chronic phlegmon, and entero–cutaneous fistulas are other mechanical indications for operative intervention which can be dealt with after careful radiographic studies to delineate the anatomy and preoperative patient preparation.

Fistulas to the urinary tract with recurrent urinary tract infections may not constitute an urgent indication for operation but continued soiling of the urinary tract could result in progressive renal dysfunction arguing for earlier rather than later intervention in these situations. Although some patients will respond to medical therapy, vast majority of patients will require surgical intervention [31–34]. Entero–vesical fistulas are treated with takedown of the fistula and closure of the bladder while ureteral fistulas may require resection with re-anastomosis or re-implantation of the ureter.

Finally, progression of the disease with persistent symptoms despite maximal medical therapy may also be the impetus for considering the surgical option. Regardless of the indication, the philosophy of therapy remains the same. The surgical procedure must be tailored to the individual patient with an eye toward preserving all possible small bowel length while providing the most effective palliation of the presenting complication of the Crohn disease. Surgical intervention in patients with progressive or chronic symptoms related to stricturing or fistulizing disease in the abdomen is effective in relieving symptoms and can minimize absence from school and improve overall well-being when compared to nonoperative therapy [35].

The procedure performed at the time of operation depends on the clinical situation and extent of the disease. As mentioned previously, in a patient that is acutely ill with sepsis or complete obstruction, simple diversion may be the most appropriate response. However, in most patients a more definitive procedure is performed. In pediatric patients with stricturing disease, the terminal ileum is the most common site involved and the gross appearance of diseased ileum reveals fat wrapping and bowel wall thickening (Fig. 37.2). Often the disease extends up to include the ileocecal valve and the most common approach is bowel resection extending from the proximal extent of the disease in the ileum to the ascending colon, which is usually uninvolved. Bowel continuity is restored with a primary anastomosis (Fig. 37.3).

In an effort to preserve as much bowel length as possible only gross disease is resected since recurrent disease may require additional surgery and bowel length may be shorter than normal in patients with Crohn disease leaving less margin for resection before developing issues with poor absorption [36]. The actual technical aspects of the procedure vary somewhat by surgeon and are largely a matter of training and experience. Bowel resection is carried out in the standard fashion with no need to obtain clear margins or mesenteric lymph nodes as might be required for a cancer operation. The only technical aspect of the procedure that may impact outcome is the manner in which the bowel is anastomosed.

There are a number of techniques for re-anastomosing bowel with the most surgeons performing either a hand-sewn end-to-end anastomosis or a side-to-side, functional end-to-end stapled anastomosis. There is some evidence to suggest that a stapled anastomosis may reduce the time to recurrence in patients with Crohn disease [37–45]. The reason for this is unclear and may have to do with the diameter of the resulting anastomosis or the nonreactive nature of the staples. Alternatively, it may have more to do with the anatomic orientation of the anastomosis rather than the manner in which the bowel is re-approximated [46]. The other reported benefit of a stapled anastomosis has to do with the incidence of postoperative complications. Anastomotic leaks and intra-abdominal abscesses are less common with the stapled anastomosis in some series but not in others [41, 47–50].

Complications following bowel resection and anastomosis in Crohn patients are common and are most often infectious in nature. Wound infections are most common and occur in as many as 20% of patients while more serious intra-abdominal infection related to anastomotic leak occur in 3–10% [41, 51]. Wound complications are treated with local care while anastomotic complications may require reoperation with revision or temporary diversion with an ostomy.

Diffuse small bowel disease with skip lesions or strictures that do not involve the ileocecal valve allows for some additional options in surgical treatment. Short segments are often resected with primary anastomosis when it represents the only area of disease. However, multiple short segments or longer segments up to 20 cm in length may be amenable to stricturoplasty rather than resection in an effort to preserve bowel length.

The technique entails a longitudinal enterotomy through the strictured segment with closure in a transverse fashion to relieve the obstruction (Heineke-Mikulicz stricturoplasty) (Fig. 37.4). While it seems somewhat counterintuitive to leave the diseased bowel in situ, the results following this operation are quite good even when applied to multiple strictures in the same patient [52]. Surprisingly, the rate at which recurrent disease occurs at the stricturoplasty site is low [53] and the technique has been used for many years with results from long-term follow-up studies supporting its use [54]. Recurrence rates following stricturoplasty are on the order of 15% at 2 years and 20% at 5 years [55].

There are a number of technical modifications of this technique that allow for longer segments to be preserved while relieving obstruction [56–60]. In a study of 102 patients undergoing a nonconventional stricturoplasty for a longer segment of intestine, there were 48 ileoileal side-to-side isoperistaltic strictureplasties, 41 widening ileocolic stric­turoplasties, 32 ileocolic side-to-side isoperistaltic strictureplasties, which were associated with Heineke-Mikulicz strictureplasties in 80 procedures or with short segmental bowel resections or both in 47 procedures. The postoperative complication rate was 5.7% which is consistent with the complication rate from the more common Heineke-Mikulicz strictureplasty. The 10-year clinical recurrence rate was 43% and the recurrence rate at the previously affected site was only 0.8% [58]. In another study long segment stricturoplasty (>20 cm) was reported to have recurrence rates that are not significantly different than that for shorter segment disease. Recurrence rates were 20–35% at 3 years, 50% at 5 years, and 60% at 10 years with no difference in complications between the groups [57].

In some very difficult situations such as long duodenal strictures, other modifications of the stricturoplasty technique can be applied. In one such case a jejunal patch was used to successfully relieve the obstruction and avoid intestinal bypass in a patient with a difficult duodenal stricture [61].

The most recent advances in surgical treatment of intra-abdominal complications of Crohn disease have been the application of minimally invasive surgical techniques. As with many of the other conditions to which laparoscopic techniques have been applied, multiple studies have demonstrated a decrease in hospital length of stay, more rapid return to work, less postoperative narcotic use, and improved cosmetic results. Similarly, multiple studies of laparoscopic techniques applied to surgery for Crohn disease in children and adults have also suggested shorter hospital stays, decreased need for parenteral narcotics, and faster return to a regular diet [62–71]. However, a recent Cochrane analysis has shown no difference in length of stay or duration of ileus [72] and the morbidity of the laparoscopic approach is equivalent to open surgery [73], Thus, although the benefits of the laparoscopic approach may be limited to improved cosmesis at the expense of longer operating time, there is a trend toward increased use of minimally invasive techniques and the outcomes are at least equivalent to open surgery.

The techniques employed often use laparoscopic exploration of the abdomen with mobilization of the diseased bowel segment. Various sealer/cutting devices facilitate taking the mesentery of involved segments without additional blood loss and stapling devices allow for dividing the bowel at the margins of disease. Anastomosis may be carried out extracorporeally after the diseased segment is delivered from the abdomen through a small incision or intracorporeally using the laparoscopic stapling devices. These techniques can also be incorporated into the single site surgical approach to achieve “scarless” operations [74] although the benefit is purely cosmetic and the outcomes have not been tested.

Although complicated disease involving fistulas or phlegmon was considered a relative contraindication to the laparoscopic approach, many cases are now handled by experienced surgeons without an increase in complication rate [75–80]. One potential benefit of the laparoscopic approach is a reduction in postoperative adhesion formation. This carries added importance in the Crohn populations where disease recurrence is more the rule than the exception and reoperation is often necessary. Reduced adhesions facilitate subsequent operations [81] and theoretically lowers the risk of injury to the bowel and ureters. Approaching recurrent disease laparoscopically is also feasible without an increased complication rate [82, 83].

In the long run, patients’ quality of life does not appear to be impacted by the technique used at the time of surgery [83, 84]. However, the advantage of the minimally invasive approach likely extends beyond quality of life measurements. Reduced intra-abdominal adhesion formation, possible faster resumption of full enteral nutrition, and perhaps less psychological trauma related to body image issues are all of particular significance to the pediatric patient population.

Crohn colitis requires a different approach than for small bowel disease. Colonic disease is traditionally regarded as being more aggressive and the colon is not necessary for the nutritional function of the intestinal tract so some advocate subtotal colectomy rather than segmental resections when colonic involvement requires surgical intervention. However, segmental resection offers the opportunity to preserve colonic function and avoid or delay the potential for permanent ileostomy and has become the more common approach [14]. Fewer symptoms, fewer loose stools, and better anorectal function have been reported following segmental resection and the re-resection rate did not differ from patients undergoing subtotal colectomy [85, 86]. Conversely, patients with pancolitis or severe distal colonic disease have been reported to have longer disease free intervals [87] and wean from chronic medications more often when treated with subtotal colectomy or proctocolectomy when compared to those undergoing segmental resection. However, these patients also had a higher incidence of permanent diverting ileostomy [88, 89] suggesting that segmental resection for pediatric patients with colonic Crohn disease is preferable when possible. Laparoscopic techniques are possible and show similar advantages of those described in small bowel resection [90].

Approximately one third of patients with Crohn disease will develop perineal or rectal manifestations of the disease [91]. Fistulizing perineal disease is an area in which surgical intervention has classically been avoided given the risk of nonhealing wounds and incontinence. More recently, however, the use of early surgical evaluation has been found to provide important information to help guide the medical management. While fistulotomy and incision and drainage of local abscesses were fraught with long-term complications in the past, the use of new biologic agents such as infliximab have rendered early surgical intervention not only safe, but necessary for rapid control of the disease.

Medical therapy for perineal disease has been greatly improved with the advent of biologic agents yet more than half ultimately require surgical procedures [92]. Two controlled trials support the efficacy of infliximab in achieving closure of perineal fistulas [93] and the combination of infliximab and surgical treatment of fistulizing perineal disease can result in marked improvement of perineal disease which is superior to infliximab alone [94–96]. Conversely, infliximab treatment does not prevent the need for surgery for fistulizing Crohn disease [97].

Treatment algorithms in pediatric inflammatory bowel disease centers have evolved to include an aggressive surgical approach early. Examination under anesthesia is particularly useful in the pediatric population. Comprehensive rectal examination is often difficult in the clinic setting in younger patients that are unable to cooperate fully with the exam. General anesthesia in the operating room provides the ideal environment to carefully evaluate the extent of disease with delineation of fistula tracts, abscesses, and rectal strictures. A complete assessment of the extent of the disease is important to help guide medical therapy.

Once the extent of disease is determined, therapeutic measures can be performed during the same anesthetic. If fistulae-in-ano are present, they can be probed to ascertain the anatomy. Superficial tracts are treated with fistulotomy while for more complex tracts a noncutting seton placement is placed.

Initial surgical treatment may improve the response to subsequent pharmacologic therapy. Local infection can be controlled, strictures dilated, and complex fistulas delineated and controlled with seton placement. Following initiation of treatment with infliximab, the seton is removed to allow the fistula tract to close. Abscesses are drained and strictures can be sized and dilated.

Unfortunately, long-term control of perianal disease remains a challenge and diverting colostomy may be necessary to gain control of the problem in pediatric patients. In adults, as many as 20% of patients with severe perianal disease proceed to proctocolectomy with permanent ileostomy [91].

Low rectal and anal strictures caused by chronic fibrosis from chronic inflammation can be successfully treated with transanal dilations [93]. Younger pediatric patients may require dilations under anesthesia on a regular basis while older patients will tolerate dilations in the office or at home. Incontinence can result from overdilation of rectal strictures or operative damage to the muscles during fistulotomy but it is often difficult to separate the impact of the dilations ­relative to the underlying disease process. Tight irregular strictures longer than 3–4 cm without a clear lumen are a relative contraindication to dilation because perforation of the rectum is possible, particularly in small pediatric patients. Initial dilation in the operating room guided by fluoroscopy may reduce the risk of subsequent outpatient dilations. Treatment with dilations may be needed for many months and ultimately the result is dependent on systemic control of the disease process. Strictures that do not respond to chronic dilations may eventually require a diverting colostomy. The combination of anal stricture and colonic Crohn disease ultimately leads to fecal diversion in more than 50% of patients [98].