Further improvements in single embryo transfer live birth rates are anticipated with the widespread adoption of blastocyst culture [41]. However, additional selection methods will be required as the association between euploid status and standard morphological grading of the embryo is limited [42]. In particular, the use of non-invasive assessment of morphokinetics, although having the potential to improve blastocyst selection above and beyond simple grading, has limited accuracy for detecting aneuploidy. Rather, invasive testing of the embryo is likely to be beneficial as analysis of blastocysts, even in women under 25 years of age is still associated with up to 30 % of blastocysts being aneuploid [43] and this increases to almost 80 % in women over 45 years of age. Accordingly, there are now several randomized controlled trials all consistently showing improved clinical pregnancy rates with comprehensive chromosome analysis of blastocysts as compared to selection based on blastocyst morphological grading alone.