Sertoli-Leydig Cell Tumor (Arrhenoblastoma)

Chapter 142 Sertoli-Leydig Cell Tumor (Arrhenoblastoma)



INTRODUCTION



Description: A Sertoli-Leydig cell tumor is a rare sex cord tumor of the ovary that carries male elements and may be associated with virilization. Tumors vary in size but generally are 5 to 15 cm in diameter.

Prevalence: Very rare (<0.5% of ovarian tumors).

Predominant Age: Older than 30 (70%), <10% older than 50.

Genetics: No genetic pattern.


ETIOLOGY AND PATHOGENESIS



Causes: Unknown.

Risk Factors: None known.


CLINICAL CHARACTERISTICS



Signs and Symptoms



• Asymptomatic

• Adnexal enlargement (1.5% bilateral)

• Abdominal swelling or pain

• Ascites (4%)

• Oligomenorrhea or amenorrhea

• Loss of female secondary sex characteristics (breast atrophy, loss of body contours)

• Virilization or masculinization (one third of patients; acne, hirsutism, temporal balding, deepening of voice, clitoral enlargement)


DIAGNOSTIC APPROACH



Differential Diagnosis



• Adrenal virilizing tumors

• Benign adnexal masses (corpus luteum, follicular cyst)

• Endometriosis

• Hydrosalpinx

• Paratubal cyst

• Appendiceal abscess

• Ectopic pregnancy

• Pedunculated leiomyomata

• Pelvic or horseshoe kidney

• Nongynecologic pelvic masses


Associated Conditions: Virilization, hirsutism, clitoral enlargement.


WORKUP AND EVALUATION



Laboratory:

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Jun 6, 2016 | Posted by in GYNECOLOGY | Comments Off on Sertoli-Leydig Cell Tumor (Arrhenoblastoma)

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