58 PRURITUS General Discussion The sensation of itching, or pruritus, is the most common symptom of dermatologic conditions, but may also be associated with systemic disease, even in the absence of primary cutaneous findings. Histamine is the main mediator of itching, but other mediators may be involved, including serotonin, neuropeptides, and prostaglandins. Pruritus is frequently encountered as a symptom of common dermatologic conditions such as atopic dermatitis, contact dermatitis, psoriasis, and urticaria. Additional dermatologic causes of itching are outlined below. When primary skin findings are absent, the approach shifts to attempting to detect an underlying systemic disorder. In patients with pruritus, the prevalence of underlying systemic disease ranges from 10% to 50%. If no specific dermatologic disorder is identified after a thorough history and physical examination, laboratory and radiologic tests should be ordered to try to identify the presence of systemic disease. Medications That Cause Cholestasis or Cholestatic Hepatitis Allopurinol Ampicillin Anabolic steroids Antibiotics • Amoxicillin/clavulanic acid • Azithromycin • Clarithromycin • Dapsone • Erythromycin • Flucloxacillin • Nitrofurantoin • Trimethoprim/sulfamethoxazol Arsenic Azathioprine Barbiturates Benzodiazepines Captopril Carbamazepine Chlorpromazine Chlorpropamide Cimetidine Clindamycin Co-trimoxazole Cyclohexylpropionate Cyclosporin A Cyproheptadine Cytosine-arabinoside Danazol Erythromycin Fosinopril Gold Haloperidol Infliximab Loracarbef Mesalamine Methimazole Nifedipine NSAIDs • Diclofenac • Ibuprofen • Nimesulide • Sulindac Phenytoin Pizotyline Prochlorperazine Propoxyphene Risperidone Sex steroids Tamoxifen Terbinafine Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: ARTHRITIS AND ARTHRALGIA HAIR LOSS HYPOTHYROIDISM SYNCOPE Stay updated, free articles. Join our Telegram channel Join Tags: Instant Work-ups A Clinical Guide to Medicine Aug 17, 2016 | Posted by admin in PEDIATRICS | Comments Off on PRURITUS Full access? Get Clinical Tree
58 PRURITUS General Discussion The sensation of itching, or pruritus, is the most common symptom of dermatologic conditions, but may also be associated with systemic disease, even in the absence of primary cutaneous findings. Histamine is the main mediator of itching, but other mediators may be involved, including serotonin, neuropeptides, and prostaglandins. Pruritus is frequently encountered as a symptom of common dermatologic conditions such as atopic dermatitis, contact dermatitis, psoriasis, and urticaria. Additional dermatologic causes of itching are outlined below. When primary skin findings are absent, the approach shifts to attempting to detect an underlying systemic disorder. In patients with pruritus, the prevalence of underlying systemic disease ranges from 10% to 50%. If no specific dermatologic disorder is identified after a thorough history and physical examination, laboratory and radiologic tests should be ordered to try to identify the presence of systemic disease. Medications That Cause Cholestasis or Cholestatic Hepatitis Allopurinol Ampicillin Anabolic steroids Antibiotics • Amoxicillin/clavulanic acid • Azithromycin • Clarithromycin • Dapsone • Erythromycin • Flucloxacillin • Nitrofurantoin • Trimethoprim/sulfamethoxazol Arsenic Azathioprine Barbiturates Benzodiazepines Captopril Carbamazepine Chlorpromazine Chlorpropamide Cimetidine Clindamycin Co-trimoxazole Cyclohexylpropionate Cyclosporin A Cyproheptadine Cytosine-arabinoside Danazol Erythromycin Fosinopril Gold Haloperidol Infliximab Loracarbef Mesalamine Methimazole Nifedipine NSAIDs • Diclofenac • Ibuprofen • Nimesulide • Sulindac Phenytoin Pizotyline Prochlorperazine Propoxyphene Risperidone Sex steroids Tamoxifen Terbinafine Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: ARTHRITIS AND ARTHRALGIA HAIR LOSS HYPOTHYROIDISM SYNCOPE Stay updated, free articles. Join our Telegram channel Join Tags: Instant Work-ups A Clinical Guide to Medicine Aug 17, 2016 | Posted by admin in PEDIATRICS | Comments Off on PRURITUS Full access? Get Clinical Tree
