(1)
Medical School, University of Porto, Porto, Portugal
6.1 Definition, Incidence and Main Risk Factors
Postpartum haemorrhage occurs more frequently in the first 2 h after delivery and is classified as early or primary postpartum haemorrhage (i.e. occurring in the first 24 h after birth). Late or secondary postpartum haemorrhage (appearing after the first 24 h) is outside the aim of this chapter.
There is no worldwide agreement on the definitions of postpartum haemorrhage and major postpartum haemorrhage. Some define postpartum haemorrhage as blood loss exceeding 500 ml and major postpartum haemorrhage as blood loss exceeding 1000 ml. Others define postpartum haemorrhage as blood loss exceeding 500 ml in vaginal deliveries and exceeding 1000 ml at caesarean section. The limitation of all these definitions is the difficulty in quantifying blood loss accurately, particularly in vaginal deliveries. Collector bags can be used for this purpose, but blood frequently falls outside; amniotic fluid and urine may be collected and both will affect quantification. Weighing of swabs is routinely performed in some centres, but the practice is time-consuming and not widely disseminated, and similar inaccuracies to those referred for collector bags may occur. The most widely used alternative is visual estimation of blood loss, but this has well-known limitations, although improved accuracy may be achieved with visual aids, where the appearance of different blood quantity losses is depicted on photographs/drawings (Fig. 6.1). An additional problem arises from the fact that small women and those with pre-existing anaemia may decompensate with lesser quantities of blood loss.
Fig. 6.1
Quantification of blood loss based on drawings
Another definition of postpartum haemorrhage is a reduction in the haematocrit exceeding 10 %, but routine blood analysis before and after birth is rarely practised in low-risk labours, where the majority of complications occur. The need for blood transfusion is an alternative criterion, but it is used mainly in research settings, it leaves out less severe cases of haemorrhage, and transfusion criteria may vary between centres.
From a clinical point of view, the most important factor to define postpartum haemorrhage is the one that should trigger a response from the healthcare team. In the majority of situations, this occurs because profuse and/or persistent genital bleeding is witnessed to occur spontaneously after birth or when uterine massage is performed. Bleeding may be mild and rapidly reversible, so it is important to separate the concept of major postpartum haemorrhage, where more complex interventions need to be considered. Blood loss exceeding 1000 ml or a heart rate approaching the systolic blood pressure is probably the most useful criteria, from a clinical point of view. The “shock index”, defined as the heart rate divided by systolic blood pressure, is used in other areas of Medicine and has recently been applied to postpartum haemorrhage. It is considered abnormal when exceeding 0.9.
The three major causes of early postpartum haemorrhage are uterine atony, which is responsible for about 70–80 % of cases, genital tract lesions accounting for 10–15 % of cases and retained placental tissue. Partial placental retention is usually associated with recurring uterine atony and haemorrhage. Abnormally adherent placenta (accreta, increta and percreta) is normally associated with haemorrhage when attempts are made to remove the placenta, and its incidence has been increasing in some parts of the world because of escalating caesarean section rates. Rarer causes of postpartum haemorrhage are uterine inversion, uterine rupture and maternal bleeding disorders. Uterine inversion is thought to be caused mainly by mismanagement of the third stage of labour, namely by excessive pressure on the uterine fundus, premature traction on the umbilical cord or excess traction during manual removal of an abnormally adherent placenta. Less frequently it occurs after an episode of coughing or vomiting during the third stage of labour.
The incidence of early postpartum haemorrhage varies widely, depending on the criteria used for the diagnosis, the population studied and the methods used for prevention, but it is reported to occur in 2–10 % of all deliveries. The most important risk factors are listed in Table 6.1, but many cases occur in women where these are not present.
Table 6.1
Risk factors for postpartum haemorrhage
High parity |
High uterine volume – multiple pregnancy, macrosomia, polyhydramnios |
Caesarean delivery and instrumental vaginal delivery |
Prolonged or precipitate labour |
Labour induction and acceleration |
Placental abruption |
Uterine leiomyomas and malformations |
Maternal bleeding disorders |
Corioamnionitis |
Placenta praevia and abnormally adherent placenta |
Pre-eclampsia |
Amniotic fluid embolism |
Previous postpartum haemorrhage |
6.2 Consequences
Postpartum haemorrhage remains an important cause of maternal mortality, in both low- and high-resource countries. In European countries, maternal deaths due to postpartum haemorrhage occur in about 0.003 % of all births, and this incidence has not changed significantly over the last 30 years.
Less is known about maternal morbidity associated with postpartum haemorrhage, but most of it is related to the side effects of treatment. Some surgical procedures are associated with loss of fertility (conservative treatments and hysterectomy), infectious morbidity, urologic lesion and intensive care unit stay. Other complications are associated with allergic reactions to medication, colloids and blood replacement products. Birth canal lacerations may also occur as a consequence of mechanical treatments, but these seldom have long-term consequences. Decreased perfusion of the pituitary gland for prolonged periods of time has been associated with secondary panhypopituitarism (Sheehan’s syndrome), but this complication is currently very rare in high-resource countries.
6.3 Diagnosis
Postpartum haemorrhage can be defined as profuse and/or persistent genital bleeding occurring spontaneously after birth or when uterine massage is performed. The diagnosis may be triggered by routine clinical re-evaluation, maternal complaints of dizziness and loss of vision, maternal paleness or by the detection of tachycardia or hypotension. The main clinical usefulness of this definition is that it constitutes a trigger for action from the healthcare team.
The diagnosis of major postpartum haemorrhage implies the same findings, but in addition blood loss exceeds 1000 ml (by quantification or visual estimation) or maternal heart rate approaches systolic blood pressure (the shock index exceeds 0.9).
6.4 Clinical Management
Management of postpartum haemorrhage involves two major components – support of maternal circulation/oxygenation and treatment of the underlying cause. When an anaesthetist and an obstetrician are present in the room, the responsibility for these two aspects is usually divided among them. In the remaining situations, the person in charge needs to take care of both.
6.4.1 Anticipating the Situation
When the risk factors listed in Table 6.1 are identified, increased surveillance usually allows earlier diagnosis and intervention. Continuous monitoring of maternal pulse and blood pressure should be considered in the first stages of any abnormal genital bleeding, in addition to frequent re-evaluation of haemorrhage and uterine contracture.
6.4.2 Clearly Verbalising the Diagnosis
It is important that the whole team of healthcare professionals is aware of the diagnosis of postpartum haemorrhage, so that they can act accordingly, and therefore this needs to be clearly verbalised, without unnecessarily alarming the labouring woman and her companion.
6.4.3 Asking for Help
One of the first measures should be to summon urgently at least two midwives, a senior obstetrician and an anaesthetist. As stated above, the presence of an anaesthetist guarantees a safer management of basic circulatory and respiratory functions, as well as fluid balance. Care is however needed to maintain good communication between both sides at all times, so that there is coordinated management of the situation.
6.4.4 Initial Evaluation of the Cause of Haemorrhage
A quick evaluation needs to be carried out to establish the most likely cause of haemorrhage. This involves assessment of uterine contracture to diagnose uterine atony, a speculum evaluation to detect lacerations of the birth canal and a re-evaluation of the placenta to establish whether it is complete (no missing cotyledons on the maternal side, no lacerated vessels on the placental margin on the fetal side). Abnormally adherent placenta is usually diagnosed when placental extraction fails, and uterine inversion is diagnosed by bimanual examination. The rarer causes of uterine rupture and maternal bleeding disorders are usually considered only after the initial measures for treatment of postpartum haemorrhage have failed.
6.4.5 Support of Maternal Circulation and Oxygenation
6.4.5.1 Venous Catheterisation and Blood Volume Replacement
One of the first measures should be to guarantee adequate access for fluid perfusion, by catheterising a vein with a large bore catheter (14G or 16G). If major postpartum haemorrhage is identified, a second vein should be catheterised and at the same time blood collected for full blood count, coagulation studies and cross-matching. Fluid replacement with crystalloids (saline, Ringer’s lactate) at high perfusion speeds should follow, avoiding dextrose solutions as they may worsen acidosis. About three litres of crystalloids are required to replace one litre of blood loss, because of loss to the extravascular space. In previously healthy women, a 1.5 l blood loss can usually be compensated just with the use of crystalloids. With further loss, replacement with colloids and blood products needs to be considered (see below).
6.4.5.2 Maternal Monitoring
Continuous monitoring of maternal heart rate and oxygen saturation should be started promptly and blood pressure measured every 5–10 min. Consideration should also be given to electrocardiographic monitoring, particularly with major postpartum haemorrhage or when there is loss of consciousness.
6.4.5.3 Bladder Catheterisation and Measurement of Urinary Output
Bladder catheterisation is needed to measure urinary output, which should be kept above 30 ml/h, and to allow more effective external uterine massage (see below).
6.4.5.4 Maintain Maternal Oxygen Supply to the Brain
It is important to guarantee adequate oxygen supply to the brain, and for this the woman should be placed in a slight head–down position or alternatively her legs raised to increase venous return. Oxygen should be administered by face mask, starting at 30 %, 10–15 l/min, and thereafter adapting according to oxygen saturation levels.
6.4.5.5 Decision to Start Colloids
When blood loss exceeds 1.5 l or there is difficulty in maintaining normal maternal blood pressure with crystalloids, administration of colloids needs to be considered. The latter includes albumin, dextran, gelatin and hydroxyethylamide. These substances assure a higher intravascular volume and some improve oxygen transport in the microcirculation, but they all carry a small risk of anaphylaxis. The frequency of severe reactions (shock, cardiorespiratory arrest) is 0.003 % for albumin, 0.008 % for dextran, 0.038 % for gelatin and 0.006 % for hydroxyethylamide. Colloid volumes exceeding 1000–1500 ml per day may also affect coagulation tests.