PREGNANCY SUMMARY

No reports describing the use of mafenide during human pregnancy have been located. The cream formulation is absorbed into the systemic circulation and exposure of the embryo–fetus probably occurs. The anti-infective did not cause fetal toxicity in the only animal species tested. Although the mechanism of action is different from the sulfonamides, it is closely related to that class of agents (see also Sulfonamides). Because of its indication for severe burns, it should not be withheld because of pregnancy.