Krukenberg Tumor

Chapter 133 Krukenberg Tumor



INTRODUCTION



Description: A Krukenberg tumor is a metastatic tumor (generally from the gastrointestinal tract) that is characterized by large signet-ring cells. The most common site or origin is the stomach or large intestine.

Predominant Age: Postmenopausal.

Genetics: No genetic pattern.


ETIOLOGY AND PATHOGENESIS



Causes: Metastatic spread of carcinoma from the gastrointestinal tract (most commonly the stomach or colon). Metastatic breast cancer may appear similar histologically.

Risk Factors: None known.


CLINICAL CHARACTERISTICS



Signs and Symptoms



• Asymptomatic

• Adnexal enlargement (bilateral solid adnexal masses in an older patient should always suggest the possibility of a gastrointestinal tract source)

• Metastatic tumors from the gastrointestinal tract to the ovary can be associated with sex hormone production, usually estrogen.


DIAGNOSTIC APPROACH



Differential Diagnosis



• Benign adnexal masses (corpus luteum, follicular cyst)

• Endometriosis

• Hydrosalpinx

• Paratubal cyst

• Appendiceal abscess

• Ectopic pregnancy

• Pedunculated leiomyomata

• Pelvic or horseshoe kidney

• Nongynecologic pelvic masses

• Breast cancer

• Lung cancer

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Jun 6, 2016 | Posted by in GYNECOLOGY | Comments Off on Krukenberg Tumor

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