FIGURE 22.1 Success in ovulation induction. Long-term effects and complications should be part of counseling.
Conclusion
Subfertile couples suffering from anovulation should be well informed on treatment effect on the cycle level in terms of ovulation as well as pregnancy and live birth, on side effects, and on the reproductive life of the woman and her family, thus allowing shared decision making. Clinical research should follow this need. Studies assessing the effectiveness of ovulation induction in the short term should report on ovulation rates and on live birth over a multiple number of cycles. Preferably, studies should also assess short- as well as long-term (side) effects, including subsequent pregnancies and future cardiovascular health.
Level of Evidence of Statements
Statement | Level of Evidence |
Success of ovulation induction has multiple dimensions and depends on the stage and strategy of treatment. | 2a |
For cost-effectiveness analysis, fertility treatments are more difficult than for other types of medical care. | 4 |
The definition of success of ovulation induction in clinical research can differ from the definition of success in daily practice. | 4 |
Grade of Strength for Recommendations
Recommendation | Grade Strength |
Studies should report on multiple cycles on the outcomes of ovulation and ongoing pregnancy. | B |
