Christopher P. Coppola, Alfred P. Kennedy, Jr. and Ronald J. Scorpio (eds.)Pediatric Surgery2014Diagnosis and Treatment10.1007/978-3-319-04340-1_71
© Springer International Publishing Switzerland 2014
Hepatoblastoma
(1)
Department of Haematology/Oncology, Janet Weis Children’s Hospital, 100 N. Academy Av. MC 13-20, Danville, PA 17822, USA
1.
Pathophysiology:
(a)
Incidence: 1 % of all pediatric malignancies.
(b)
Age at diagnosis: 80 % between 6-months-old and 3-years-old. Neonatal and school aged children are also seen.
(c)
Etiology: Unknown.
(i)
Possible factors.
1.
Extreme prematurity and very low birth weight less than 1,000 g.
2.
Fetal alcohol syndrome.
3.
Hemi hyperplasia.
4.
Oral contraceptive use during pregnancy.
(ii)
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Chromosomal Abnormalities:
1.
Beckwith-Weidman syndrome.
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