Chapter 511 Goodpasture Disease Scott K. Van Why, Ellis D. Avner Goodpasture disease is characterized by pulmonary hemorrhage and glomerulonephritis. The disease results from the attack of these normal organs by antibodies directed against specific epitopes of type IV collagen within the alveolar basement membrane in the lung and glomerular basement membrane (GBM) in the kidney. The etiology of these antibodies is unknown. Pathology Kidney biopsy shows crescentic glomerulonephritis in most patients. Immunofluorescence microscopy demonstrates continuous linear deposition of immunoglobulin G along the GBM (Fig. 511-1). Figure 511-1 Immunofluorescence micrograph demonstrating the continuous linear staining of immunoglobulin G along the glomerular basement membrane in Goodpasture disease (×250). Clinical Manifestations Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Chronic Recurrent Aspiration Arboviral Encephalitis in North America Isolated Glomerular Diseases with Recurrent Gross Hematuria American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi) Stay updated, free articles. Join our Telegram channel Join Tags: Nelson Textbook of Pediatrics Expert Consult Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off on Goodpasture Disease Full access? Get Clinical Tree
Chapter 511 Goodpasture Disease Scott K. Van Why, Ellis D. Avner Goodpasture disease is characterized by pulmonary hemorrhage and glomerulonephritis. The disease results from the attack of these normal organs by antibodies directed against specific epitopes of type IV collagen within the alveolar basement membrane in the lung and glomerular basement membrane (GBM) in the kidney. The etiology of these antibodies is unknown. Pathology Kidney biopsy shows crescentic glomerulonephritis in most patients. Immunofluorescence microscopy demonstrates continuous linear deposition of immunoglobulin G along the GBM (Fig. 511-1). Figure 511-1 Immunofluorescence micrograph demonstrating the continuous linear staining of immunoglobulin G along the glomerular basement membrane in Goodpasture disease (×250). Clinical Manifestations Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Chronic Recurrent Aspiration Arboviral Encephalitis in North America Isolated Glomerular Diseases with Recurrent Gross Hematuria American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi) Stay updated, free articles. Join our Telegram channel Join Tags: Nelson Textbook of Pediatrics Expert Consult Jun 18, 2016 | Posted by admin in PEDIATRICS | Comments Off on Goodpasture Disease Full access? Get Clinical Tree
