Fasting
Age
Solid food, milk
(hour)
Liquids
(hour)
Under 6 months
4
3
6–36 months
6
4
>36 months
8
4
- 2.
Premedication
The main purpose of premedication for pediatric lens surgery involves the following aspects: to ease the tension and preoperative anxiety in the pediatric patient, to reduce respiratory secretions, and to adjust the autonomic nerve activity and eliminate or weaken adverse vagal reactions.
The selection of premedication should be based on the pediatric patient’s condition and duration of lens surgery [3]. ① Diazepams: For children with preoperative fear and separation anxiety, midazolam syrup (0.25 mg/kg) for oral administration or intravenous/intramuscular injections (0.05 ~ 0.1 mg/kg) can be chosen 30 min preoperatively to calm the child. ② Anticholinergic agents: Atropine and scopolamine are the commonly used anticholinergic agents. With regard to pupil dilatation, inhibition of glandular secretion, and central sedation, scopolamine exceeds atropine, whereas, for inhibiting vagal activity, the latter is much more effective. The doses of atropine and scopolamine are 0.01 ~ 0.015 mg/kg and 0.01 mg/kg, respectively, and are injected subcutaneously 30 min before surgery to reduce respiratory secretion.
10.2 Selection of General Anesthesia Methods
General anesthesia may be divided into general anesthesia with laryngeal mask airway (LMA) and endotracheal tube. Indications vary for different anesthetic methods based on the advantages and shortcomings. The goal of anesthesia management of pediatric lens surgery is to provide smooth induction and tracheal intubation, stable intraocular pressure (IOP), well-controlled eye fixation at the primary position, and steady recovery.
10.2.1 Commonly Used General Anesthetics
- 1.
Midazolam
Midazolam is a new class of benzodiazepine containing an imidazole ring. The characteristics of midazolam solution include chemical stability, lipophilicity, rapid onset, short duration of action, low toxicity, and little effect on respiratory and circulatory systems. Additionally, midazolam can exert excellent anterograde amnesia to prevent postoperative agitation after pediatric lens surgery.
- 2.
Propofol
Propofol is an alkylphenol soluble in 10 % soybean oil, 2.25 % glycerinum, or 12 % purified lecithin. It is a new class of intravenous anesthetic with rapid onset and short duration of action. The clinical features include strong sedative effect, rapid onset, and short duration, and it allows for repetitive intravenous administration or continuous infusion. Propofol also possesses the properties of inhibiting airway reflexes to reduce the incidence of laryngospasm.
- 3.
Ketamine
Ketamine is a derivative of racemized nonbarbiturate cycloheximide. Ketamine may be used in pediatric lens surgery without mechanical ventilation and be intravenously administered for general anesthesia induction or used together with other anesthetics for maintenance. Although ketamine has little influence on cardiovascular or respiratory systems, it has obvious shortcomings, including IOP elevation and intraoperative nystagmus. Additionally, ketamine can induce increased respiratory secretions, and this is likely to trigger laryngospasm in children with URI [4].
- 4.
Fentanyl
Fentanyl is a commonly used potent analgesic; it is a type of synthetic μ-opiate receptor agonist that acts on opioid receptors located in the brain stem and spinal cord to produce an analgesic effect. A single intravenous injection of low-dose fentanyl (1 ~ 4 μg/kg) in children is used for anesthesia induction. Fentanyl is also used in conjunction with muscle relaxant for the completion of endotracheal intubation.
- 5.
Non-depolarizing muscle relaxants
Non-depolarizing muscle relaxants include atracurium, cisatracurium, vecuronium bromide, etc. They are mainly used for endotracheal intubation during anesthesia induction and postoperative emergency management for severe laryngospasm.
- 6.
Sevoflurane
Sevoflurane is a type of inhaled anesthetic that is recognized as the most promising candidate for the title of “ideal anesthetic.” It is widely used in pediatric anesthesia, particularly in anesthesia for minor surgery and ambulatory surgery. Sevoflurane has obvious advantages in pediatric lens surgery, such as rapid onset of anesthesia, short induction period, short recovery time, and no irritation to the airway. Nevertheless, it has an obvious shortcoming that manifests postoperatively; the occurrence rate of restlessness in children is higher than that with isoflurane.
- 7.
Dexmedetomidine
Dexmedetomidine is a highly selective α 2-adrenoceptor agonist whose primary site of action is locus ceruleus. It can inhibit neuronal firing activity and block sympathetic ganglia, thus producing sedative and analgesic effects without respiratory inhibition. A clinical study from Zhongshan Ophthalmic Center (ZOC) indicated that administration of 1–2 μg/kg of dexmedetomidine can significantly mitigate preoperative agitation/crying and reduce postoperative agitation in children receiving cataract surgery.
10.2.2 Methods of Delivering General Anesthesia
Selection of the method of delivering anesthesia for pediatric lens surgery should be evaluated comprehensively based on the physical status of the pediatric patient and the type of lens surgery. Patients may suffer from respiratory inhibition, laryngospasm, and even life-threatening complications due to hypoxia when receiving conventional intravenous anesthesia with ketamine or ketamine and propofol without intubation. Although surgery can be completed smoothly with general anesthesia combined with endotracheal intubation, the endotracheal intubation and extubation can increase IOP. In particular, extubation may lead to an increased risk of complications.
Laryngeal mask airway (LMA) is an artificial supraglottis airway device invented in 1981 by a British anesthesiologist Brain based on the anatomy of the larynx. Compared with endotracheal intubation, LMA has a number of advantages: less injury to the airway, less cardiovascular reactions, and no need to use muscle relaxant. Therefore, the use of LMA in pediatric lens surgery can significantly improve the quality of airway management with less complications (Fig.10.1).
Fig. 10.1
Laryngeal mask airway (LMA) compared with endotracheal intubation: far less injury and irritation to the respiratory tract. (a) Laryngeal mask airway insertion, (b) endotracheal intubation
10.2.2.1 General Anesthesia using LMA
- 1.
Inhaled anesthesia induction
It is an important task for every pediatric anesthesiologist to conduct a smooth anesthesia induction when a pediatric patient needs to undergo lens surgery. And it is most important to interact with the child in a calm reassuring voice when he or she is unable to cooperate, crying, or difficult to communicate with. Pediatric anesthesiologists can also engage the child’s attention by telling stories or performing magic tricks. In addition, the presence of parents at the time of anesthesia induction may strengthen or replace premedication. If the above management does not work, intranasal dexmedetomidine or intravenous midazolam can be ultimately administered. Inhaled induction of anesthesia with sevoflurane can be performed after the child is sedated.
For a pediatric patient who is cooperative, mask inhalation of 8 % sevoflurane in oxygen at the rate of 6–8 L/min is used for anesthesia induction. The moment the child loses consciousness, the parents (if present) should be asked to leave and the focus should be on the respiratory tract (Fig.10.2).
Fig. 10.2
This 4-year-old child is actively cooperative in inhalation-induced anesthesia after being psychologically encouraged
During the course of inhaled induction with sevoflurane, most children experience “excitation,” including airway obstruction, autonomic movement of the limbs, rigidity, tachypnea, and tachycardia. As the anesthesia deepens, these symptoms usually go away within a few minutes. After the “excitation period,” intravenous access can be established. Previous study has reported that there is no response to intravenous cannulation in 3–4 min following mask inhalation of sevoflurane.
- 2.
Maintenance of anesthesia
As there is slight surgical trauma and no muscle relaxant is needed, an appropriate depth of anesthesia can be maintained via the inhalation of roughly 3 % sevoflurane during anesthesia. Additional intravenous injection of 10–20 mg propofol is administered intermittently to reduce any emerging agitation in the child, and the ventilation can be maintained by spontaneous respiration or synchronized intermittent mandatory ventilation (SIMV) when the child shows respiratory depression. The perioperative liquid supplement is administered on physiological demand given the short duration, slight surgical trauma, and minimal blood loss of lens surgery.
In lens surgery, stabilization of the eye at primary position may facilitate surgical procedures. But in clinical practice, an upward movement of the eye, also known as Bell’s phenomenon, often occurs. This phenomenon is mainly associated with insufficient depth of anesthesia; therefore, the treatment lies in increasing the depth of anesthesia by additional intravenous administration of anesthetic agents or increasing concentration of inhaled anesthetics. It is worth mentioning that special attention should be paid to changes in respiratory rhythms and amplitude in children with spontaneous ventilation, and assisted mechanical ventilation should be used if necessary. However, in a child inhaling sevoflurane with an LMA with spontaneous ventilation, the increased concentration of sevoflurane can inhibit the respiratory system. As a result, patients display a lower tidal volume and an accumulation of carbon dioxide, which may lead to a downward movement of the eye that interferes with surgical procedures. Little is known of the underlying mechanism at present, but the treatment is not difficult since the eye will return to the primary position via assisted ventilation with end-expiratory carbon dioxide concentration decreased to the normal range.
- 3.
Attention to LMA applications
Different from endotracheal intubation, which can completely isolate the respiratory tract, the LMA forms an unpressurized sealing loop in the throat by separating from the surrounding tissue. Hence, the pressure should not exceed 20cmH2O through mechanical ventilation, and if the pressure is too high, air leakage will occur, and the air may leak into the stomach.
The selection of LMA size depends on the child’s body weight. Based on the experience of ZOC’s anesthetic team, the 1.5-size LMA should be applied for infants less than 6 months of age (even though their weight is less than 5 kg). Moreover, due to the soft tissue and structure of the infant, the median method can be adopted when the LMA is inserted, with the success rate over 95 %. Before the insertion of LMA, it is not necessary to have released all the air from the cuff because it can be inserted more easily with the cuff inflated. After the location is confirmed, there is no need to inject air into the cuff of LMA. If resistance occurs while the median method is being used for LMA insertion, a rotation method should be adopted to insert the LMA. Due to the narrow pharyngeal cavity of the infant in addition to the loose connective tissue, avoid any violent insertion that may induce hemorrhage in the oropharynx mucosa.
When an LMA is used, special attention should be paid to the following issues: (1) It is contraindicated for patients with full stomach and residual gastric contents. (2) Due to the higher airway pressure (>20cmH2O), this can easily lead to air leakage into the stomach, which may induce vomiting. Patients with severe obesity or low lung compliance are recommended to undergo assisted or controlled breathing with LMA. (3) It is contraindicated in patients with potential airway obstruction, such as tracheal compression, tracheomalacia, pharyngolaryngeal neoplasm, abscess, and hematoma. (4) Laryngospasm can easily occur when LMA is inserted under insufficient anesthesia, and this should be avoided. (5) Jaw lift is not allowed after the LMA is inserted; otherwise, laryngospasm or location shift will occur. (6) In the case of patients with abundant respiratory secretions, it is not easy to clear them using LMA.
10.2.2.2 General Anesthesia with Endotracheal Intubation
The clinical experience at ZOC has shown that the majority of pediatric patients take anesthesia using LMA for lens surgery. But in some children, the LMA is found to be still not in alignment after being adjusted repeatedly. Therefore, it is necessary to switch to general anesthesia with endotracheal intubation in order to ensure the airway safety of the child.
- 1.
Rapid intravenous induction
This is commonly used in pediatric lens surgery, with drug use mode of anesthesia induction as follows: intravenous general anesthetics + narcotic analgesics + muscle relaxants (see Table 10.2). Intravenous general anesthetics consist of etomidate, imidazole, diazepam, and propofol. Narcotic analgesics include ketamine and fentanyl. Muscle relaxants are made up of atracurium, vecuronium, and cisatracurium.
Table 10.2
Commonly used drugs and dosage for intravenous induction
Drug names
Usual dose (mg/kg)
Etomidate
0.3–0.4
Imidazole, diazepam
0.1–0.4
Propofol
2–3
Fentanyl
0.002–0.04
Atracurium
0.4–0.6
Vecuronium
0.09–0.1
Cisatracurium
0.15–0.2
- 2.
Endotracheal intubation
Due to age-associated anatomical differences, there are some technical differences between laryngoscopy in infants and young children and that in adults. Since an infant’s glottis is higher, it is “more forward” under laryngoscope observation; besides, it is difficult to control the epiglottis with a laryngoscopic blade since the infant’s epiglottis is longer than that of an adult and it is hard and slippery in a U shaped. Thus, in the case of children under 2 years old, a straight laryngoscope blade is more commonly used. Since the narrowest portion of the pediatric airway is beneath the glottis, be sure not to insert the catheter too violently if resistance is felt, even if it has been passed through the glottis without difficulty.
- 3.
Maintenance of anesthesia
It is necessary to maintain sufficient depth of anesthesia during the course of surgery to avoid the cough reflex induced by tracheal tube stimulation. Apart from the use of muscle relaxants at the time of tracheal intubation, there is no need for additional muscle relaxant during the process of surgery. The pattern of controlled respiration is adopted during anesthesia, with an intermittent assisted intravenous injection of 10–20 mg propofol to reduce emergence agitation in the child.Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree