Evidence-Based Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

Chapter 12
Evidence-Based Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents


Heather A. Jones and Annie E. Rabinovitch


OVERVIEW OF THE DISORDER


Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder marked by age-inappropriate levels of inattention and/or hyperactivity and impulsivity. It is one of the most common psychological disorders of childhood (Salmeron, 2009); 8.7% of children ages 8 to 15 in the United States meet diagnostic criteria for ADHD (Froehlich et al., 2007). Although the detection of true sex differences may be limited by an underrepresentation of females in ADHD research (Arnold, 1996), epidemiological data suggest that in nonclinical samples, differences between boys and girls are approximately 3:1 (Szatmari, Offord, & Boyle, 1989). In clinical populations, the ratio climbs to 9:1 (Gershon, 2002). Children and adolescents with ADHD typically present as predominantly inattentive (i.e., solely clinically significant inattentive symptomatology), combined (i.e., clinically significant symptoms of hyperactivity/impulsivity and inattention), or predominantly hyperactive/impulsive (i.e., solely clinically significant symptoms of hyperactivity and impulsivity). Accordingly, symptom profiles for this population are considered to be largely heterogeneous in nature (Musser, Galloway-Long, Frick, & Nigg, 2013). That is to say, two youth with ADHD may look clinically quite distinct from one another.


As a result of their disorder, youth with ADHD experience significant functional impairment most often at home, at school, and with peers. The home lives of youth with ADHD are often marked by high levels of family stress (Deault, 2010) and conflicted parent–child relationships (DuPaul, McGoey, Eckert, & VanBrakle, 2001), as managing the behaviors of children with ADHD can be challenging and stressful (Podolski & Nigg, 2001). With regard to school impairment, symptoms of hyperactivity/impulsivity may make it difficult for children with the disorder to remain seated or still when appropriate. Similarly, symptoms of inattention (e.g., distractibility, difficulty following instructions) may interfere with a child’s ability to complete schoolwork successfully. Thus, excessive levels of hyperactivity or intrusiveness may be considered aversive by peers (Whalen & Henker, 1992) and in turn may serve to isolate children with the disorder.


Diagnostic Criteria


Both the fourth text revision and the newly published fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR, DSM-5) (American Psychiatric Association [APA], 2000, 2013) differentiate among three presentations (formerly subtypes) of the disorder: predominantly inattentive, predominantly hyperactive/impulsive, and combined. These presentations are distinguished by specific clusters of symptoms present in the individual. To receive a diagnosis of ADHD, a child or adolescent must demonstrate at least six symptoms of inattention (inattentive presentation), hyperactivity/impulsivity (hyperactive/impulsive presentation), or inattention and hyperactivity/impulsivity respectively (combined). Furthermore, symptomatology must be present for at least 6 months and must coincide with functional impairment in at least two settings (e.g., home, school, with peers).


Four notable changes in the diagnostic criteria for ADHD were made in the DSM-5.



  1. The threshold of symptoms needed for an adult diagnosis was lowered, given the reduction of symptoms that seem to manifest in adulthood (Kessler et al., 2010).
  2. Whereas the DSM-IV-TR specified that symptoms must be present before age 7, in the DSM-5 the age of onset was increased to age 12. Research published since the DSM-IV-TR has not found significant differences in functioning, treatment response, or outcomes in comparing youth meeting an earlier relative to a later age of onset threshold (Todd, Huang, & Henderson, 2008).
  3. It is no longer necessary for symptoms to be accompanied by impairment across multiple settings for an individual to meet diagnostic criteria for ADHD; rather, symptoms must exist across settings.
  4. Whereas the DSM-IV-TR required “clear evidence of clinically significant impairment in social, academic, or occupational functioning” (APA, 2000 p. 93), language in the DSM-5 has been modified: “clear evidence that the symptoms interfere with, or reduce the quality of, social, academic, or occupational functioning” (APA, 2013, p. 60).

Thus, recent changes to the diagnostic criteria for ADHD represent advances in the scientific understanding of the disorder and better account for potential diagnostic presentations that may change across the life span.


From a developmental psychopathology perspective, ADHD-associated impairment also changes across development (Seidman, 2006). For instance, toddlers may demonstrate some of the core symptoms typically associated with ADHD (e.g., high energy); however, such symptoms generally are not accompanied by impairment (Campbell & von Stauffenberg, 2009). Longitudinal research suggests that by age 3 or 4, hyperactive/impulsive symptoms can be distinguished from normative disinhibition by virtue of both symptom severity and corresponding impairment (Barkley, 2003).


The demands in middle childhood, such as increased standards for self-control and self-monitoring and expectations of cooperation with family and peers, present many potential ways in which symptoms of ADHD may interfere with functioning. Within the home environment, research suggests that ADHD negatively impacts both the parent–child relationship and overall family functioning (for a review, see Deault, 2010). Parents of children with ADHD report significantly higher levels of parenting stress relative to children without ADHD (Mash & Johnston, 1983). Higher levels of parenting stress among families affected by ADHD may erode parents’ ability to engage in effective parenting strategies in order to manage their children’s behavior (Podolski & Nigg, 2001). As such, parent–child relationships are often characterized by greater negative emotionality, conflict, and coerciveness (DuPaul et al., 2001) relative to families of children without ADHD. Family functioning is also often affected, with greater family discord (Wells et al., 2000) and higher rates of divorce (Wymbs et al., 2008) observed among families of children with ADHD.


Within the school environment, children in middle childhood with ADHD have significant educational difficulties, including academic underachievement (DeShazo Barry, Lyman, & Klinger, 2002; Fergusson & Horwood, 1995; Fergusson, Horwood, & Lynskey, 1993) relative to control youth. Such children are also more likely to repeat academic grades (Hinshaw, 1992) and receive remedial services (Frick et al., 1991) and are more apt to face school-related disciplinary action (e.g., suspensions) compared to children without the disorder (Loe & Feldman, 2007). They are also more apt to exhibit social impairment. In fact, children with ADHD receive significantly fewer social nominations relative to their nonaffected peers (Hoza, 2007). It may be that the core symptoms of ADHD directly and negatively impact children’s ability to establish and maintain peer relationships. Indeed, Whalen and Henker (1992) found that the high levels of impulsivity and hyperactivity often seen in youth with ADHD are found to be aversive and may distance such children from peer social networks. Alternatively, inattentive symptoms may deter children with ADHD from acquiring important social skills (e.g., conversational turn taking) through observational learning (Cunningham, Siegel, & Offord, 1985). The negative impressions made on peers during childhood are resistant to treatment and may continue throughout the school-age years (Price & Dodge, 1989). Thus, the core symptoms of ADHD often result in difficulties in establishing and maintaining healthy peer relationships during childhood.


Moving into adolescence, between 50% and 80% of clinically referred children will continue to experience ADHD-related impairment (Parke et al., 2002). While the symptoms of hyperactivity and impulsivity perhaps distanced middle-age children from their peers, there is evidence to suggest that, in adolescence, these symptoms may translate into greater engagement in risky behaviors, such as dangerous driving habits (Cantwell, 1996). Within the academic realm, adolescents with ADHD fail more classes (Mannuzza, Klein, Bessler, Malloy, & Hynes, 1997), require a greater number of years to graduate high school (Weiss, Hechtman, Milroy, & Perlman,1985), and have lower rates of college attendance and graduation (Barkley, 2006) relative to controls. Research suggests that in adolescence, symptoms of hyperactivity may wane. However, impulsivity and inattention symptoms remain both prominent and impairing. Furthermore, among adolescents with ADHD, a sense of what has been termed “inner restlessness” may begin to pervade the clinical picture for these individuals (Harpin, 2005). Thus, there is evidence to suggest that in adolescence, symptom clusters may become more or less pronounced (i.e., shift from hyperactive to inattentive and impulsive), and types of impairment may also change.


Once conceptualized as a disorder of childhood, there is now evidence that ADHD is a chronic disorder, with symptoms and impairment continuing into adulthood (Pary et al., 2002). Adults affected by ADHD experience greater occupational difficulties (e.g., unemployment) (Mannuzza et al., 1997), have poorer health outcomes (Harpin, 2005), and have fewer intimate relationships (Weiss & Murray, 2003) relative to control adults. Clearly, ADHD has far-reaching developmental implications, as early deficits, particularly if left untreated, may place children with ADHD at risk for significant impairment across multiple domains over a lifetime.


Comorbidity


Complicating the clinical picture for many children with ADHD, comorbidity with other mental disorders is highly prevalent. The most common comorbid disorders are oppositional defiant disorder (ODD) and conduct disorder (CD). Barkley (2003) found that by age 7, 54% to 67% of clinically referred children with ADHD were also diagnosed with ODD. Barkley, Fischer, Smallish, and Fletcher (2004) found that between 20% and 50% of youth with ADHD went on to develop comorbid CD by middle childhood, and by adolescence, 44% to 50% met criteria for a dual diagnosis.


Comorbid internalizing disorders, including anxiety and depression, also are common. Tannock (2000) found that between 10% and 40% of children affected by ADHD within clinical samples are diagnosed with an anxiety disorder. Unlike CD, there is some evidence to suggest that anxiety may mitigate some of the negative consequences of ADHD (Pliszka, 2000). Fewer externalizing behaviors in general and less impulsivity in particular are evidenced among children with comorbid ADHD and anxiety (Jensen et al., 2001; Pliszka, 2000). As such, anxiety may buffer children with ADHD against some negative sequelae. ADHD is also highly comorbid with depression (Golubchik, Kodesh, & Weizman, 2013), with approximately 20% to 30% of youth meeting diagnostic criteria for both disorders (Barkley et al., 2004). Children with comorbid depression and ADHD may experience greater social and academic impairment relative to those children with ADHD alone (Blackman, Ostrander, & Herman, 2005). It is possible that social isolation and lack of motivation, two hallmark symptoms of depression, exacerbate existing social and academic impairment.


Finally, between 19% and 26% of children with ADHD also have a learning disorder (LD). Eighty percent of children with ADHD have learning difficulties that result in academic performance 2 years behind their nonaffected classmates (Barkley, 2003). A seminal study (Mayes, Calhoun, & Crowell, 2000) compared children with comorbid ADHD and LD to those with ADHD alone and found that both groups experienced significant learning difficulties. However, the difficulties were significantly more severe in the comorbid group, as could be expected. It is possible that LDs and specifically the inattention observed among those with ADHD represent disorders along a common spectrum.


EVIDENCE-BASED APPROACHES TO TREATMENT


From an evolutionary biology perspective, ADHD is conceptualized as a mismatch between a child’s interrelated characteristics (e.g., genetic predisposition, temperament, behavior) and his/her environmental demands (Jensen et al., 1997). Accordingly, treatments for the disorder may involve altering a child’s behavior, the environment (e.g., home life, school), or a combination of the two, in order to ameliorate consequences of the disorder (Stein, 2007). Currently, most effective interventions utilize multiple treatment components.


The Multimodal Treatment Study of Children with ADHD (MTA Cooperative Group, 1999) was the first large-scale, multisite study designed to evaluate leading treatments for ADHD. The MTA study examined for the first time the safety and relative effectiveness of stimulant medication and behavior therapy alone and in combination. The 14-month clinical trial randomized 579 youth with ADHD to one of four treatment arms: medication management, behavioral treatment, combined treatment (medication management plus behavioral treatment), and community care/referral for assessment. All treatment arms demonstrated a reduction in symptom severity. However, medication management was superior to behavioral treatment and community care. Combined treatment was no better than medication management in reducing symptom severity. In other areas of functioning, however, including child anxiety symptoms, academic performance, and social skills, the combination arm (but not medication or behavioral treatment alone) produced superior outcomes compared to routine community care at the end of treatment. The children in the combination treatment also took lower doses of medication than children in the medication group (MTA Cooperative Group, 1999).


Family and peer-based outcomes from the MTA study also have been investigated. Wells and colleagues (2000) examined parenting and family stress outcomes immediately following treatment, reporting no meaningful group-based differences across the treatment arms. It is possible that child comorbidities, such as ODD, diluted treatment effects on outcome measures. Similar nonsignificant findings were reported by Hoza and colleagues (2005) based on peer-assessed outcomes. Among a subsample of MTA participants, the authors found that despite significant reduction in ADHD symptom severity, peer functioning remained deficient. Thus, family and peer relationships may require more targeted efforts during treatment.


In terms of longer-term outcomes, an 8-year follow-up study of children enrolled in the MTA study (Molina et al., 2009) reported overall maintenance of improvement in functioning relative to pretreatment levels. However, as a whole, children were functioning significantly less well than a comparison non-ADHD classmate sample irrespective of whether children with ADHD did or did not continue to take medication after the 14-month study period. These data point toward a crucial need for treatments (or combination of treatments) that are efficacious over the long term (e.g., into the high school years).


Behavioral Interventions


Just as the symptoms and impairments exhibited by children with ADHD are varied, so too are the behavioral treatment strategies used to reduce these problems. Next we provide an overview of the types of treatment programs that have been examined in empirical research.


Behavioral Parent Training


Behavioral parent training (BPT) is likely the best-studied intervention for children with ADHD. During BPT, the foci of change are the child’s unwanted (e.g., noncompliance) and wanted (e.g., compliance) behaviors. Contrary to many other types of therapy, during BPT, the parent is the agent of change. Thus, the therapist’s role is to teach the parent to use effective behavior management strategies, monitor change, and troubleshoot difficulties. Using the behavioral principles of reinforcement and punishment, therapists instruct parents to use such skills as rewarding and attending to increase wanted behaviors as well as ignoring and employing time out to decrease unwanted behaviors.


Classroom Behavior Management


The strategies used by parents to increase compliant behaviors and decrease noncompliant behaviors can be implemented in the classroom as well. Teachers can implement reward systems for children with ADHD in the classroom using the same principles of reinforcement and punishment. The Daily Report Card (Chronis, Chacko, Fabiano, Wymbs, & Pelham, 2004; Smith, Waschbusch, Willoughby, & Evans, 2000) is a system that fosters collaboration and communication between parents and teachers. Teachers establish target behaviors, such as in-seat compliance, and send a “report card” home to parents, who then provide rewards.


Intensive Treatment Programs


The range and severity of ADHD symptoms calls for comprehensive and intensive treatment programs. The Summer Treatment Program (STP) is a 2-month, all-day program that combines a behavioral point system, daily report cards, academic skills training, social skills training, problem-solving training, and sports training, all in a summer day camp format. This program has been efficacious in decreasing ADHD symptoms and increasing behavioral functioning (e.g., Pelham et al., 2005).


Peer Interventions


It is becoming increasingly recognized that despite the success of pharmacotherapy and behavioral management to control or change some of the symptoms of ADHD, the interpersonal problems that are part of this disorder remain unchanged. The need to intervene in the area of peer relationships is important for children with ADHD, and accompanying peer problems have significant negative long-term outcomes including criminality, depression, and substance abuse (in boys) (Greene, Biederman, Faraone, Sienna, & Garcia-Jetton, 1997), and school failure, disruptive behaviors, and internalizing symptoms (in girls) (Mikami & Hinshaw, 2006).


Some data suggest that direct attempts to increase peers’ social inclusion of children with ADHD may be efficacious (Mikami et al., 2013). One intervention, Making Socially Accepting Inclusive Classrooms (MOSAIC), provides instruction to teachers and peers regarding specific behavioral changes. Teachers are taught to (1) diffuse the frustrations of children with ADHD by providing positive comments, (2) give private reprimands but public praise, (3) promote inclusive behavior by peers by suggesting areas of commonality between children with ADHD and a peer, and (4) publicly attend to the genuine strengths of children with ADHD. In one randomized controlled trial (Mikami et al., 2013), adding MOSAIC to a comprehensive behavioral treatment program resulted in enhanced sociometric ratings, more friendships, and more positive messages by peers for children than among those who received the behavioral treatment program alone.


Neurofeedback Training


Over the past decade, there have been an increasing number of commercial programs that attest to provide improved attention, impulse control, academic functioning, and social functioning as a result of neurofeedback/neurocognitive training. Using computer programs that present puzzles and tasks designed to enhance set shifting, inhibitory control, working memory, or attention, the producers of these products assert efficacious and long-lasting benefits. Unfortunately, these programs have not been subject to rigorous empirical testing, and a recent meta-analysis (Rapport, Orban, Kofler, & Friedman, 2013) suggests that these programs are not efficacious.


PARENTAL INVOLVEMENT IN TREATMENT


Commonly found among interventions for externalizing disorders, parents play an integral role in interventions for children with ADHD. Next, we review how parents contribute to these treatment programs.


Role of Parental Psychopathology


Maternal Depression


In addition to the negative consequences that ADHD can exert on youth outcomes (e.g., social isolation, parent–child conflict, academic underachievement), impairments may be heavily impacted by co-occurring parental psychopathology (e.g., anxiety: Kashdan et al., 2004; depression: Chronis-Tuscano et al., 2011). The bulk of research to date has examined the impact of maternal depression in particular on child outcomes. Despite being more common among children with comorbid ADHD and ODD/CD, mothers of children with ADHD (only) are also more likely to experience depressive symptoms as well as major depression episodes relative to mothers of control children (Chronis et al., 2003). Regardless of diagnostic status, children of depressed mothers are more likely to develop internalizing and externalizing disorders (Weissman et al., 1987), are often less socially competent (Luoma et al., 2001), and experience greater academic underachievement (Beardslee, Bemporand, Keller, & Klerman, 1983) relative to children of nondepressed mothers. Similarly, depressed mothers have been found to be less consistent and more negative in their parenting and to have greater negative expectations of their children (Downey & Coyne, 1990) relative to nondepressed mothers. In considering Patterson’s (1982) coercion model, whereby child behavior problems and parental psychopathology interact to perpetuate and maintain one another, maternal depression constitutes a significant risk factor for negative outcomes for children with ADHD (Chronis, Chacko, Fabiano, Wymbs, & Pelham, 2004).


Researchers have started to investigate whether specific treatment components to address parental psychopathology improves child, parent, or family outcomes for BPT. Specifically, Chronis-Tuscano and colleagues (2013) implemented an empirically supported adaptation to CBT targeting maternal stress and depression: the Coping with Depression Course (CWDC) (Lewinsohn, Hoberman, & Clark, 1989). Mothers were randomly assigned to receive traditional BPT or an integrated parenting intervention (IPI-A), which integrates BPT with CWDC. At posttreatment, mothers who were randomized to IPI-A experienced fewer symptoms of maternal depression and small to moderate gains with regard to negative parenting, child deviance, and child impairment. At follow-up, these mothers also saw an improvement in family functioning relative to the BPT group.


Maternal ADHD

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Sep 11, 2016 | Posted by in PEDIATRICS | Comments Off on Evidence-Based Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents

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