DELIRIUM

16 DELIRIUM



General Discussion


Delirium is an acute disturbance in mental status characterized by fluctuating levels of consciousness and an impairment of attention. Fluctuations in cognitive skills such as memory, language, and organization are common. In general, any patient with acute onset of confusion or mental deterioration should be considered to be delirious until another diagnosis is found. The following is a list of the DSM-IV criteria for delirium:






The three subtypes of delirium are hyperactive, hypoactive, and mixed. Patients with the hyperactive subtype may demonstrate restlessness, anxiety, sleep disturbances, irritability, increased psychomotor activity, emotional lability, anger, and euphoria. The presentation of the hyperactive subtype may mimic schizophrenia, psychotic disorder, or agitated dementia.


Patients with the hypoactive subtype may demonstrate reduced attention, altered arousal, decreased psychomotor activity, sadness, and disorientation. The mixed subtype is characterized by fluctuations between the hyperactive and hypoactive subtypes.


Other clinical features of delirium include delusions, hallucinations, disorganized thinking, incoherent speech, memory impairment, and disorientation to time, place, or person. Neurologic abnormalities may be present, including dysgraphia, tremor, myoclonus, reflex changes, and tone changes.


Delirium is often initially misdiagnosed as depression or dementia. In distinguishing delirium from depression, an evaluation of the onset and timeline of depressive and cognitive symptoms is important. The degree of cognitive impairment in delirium is much more severe and pervasive than in depression, with a more abrupt temporal onset. In addition, delirium manifests a disturbance in arousal or consciousness, while it is usually not a feature of depression. When considering dementia, it is important to remember that the patient with dementia is alert and does not have the disturbance of consciousness or arousal that is characteristic of delirium. Dementia is characterized by a more gradual onset of symptoms and is chronically progressive, with less impairment of the sleep–wake cycle.


Despite advances in medical technology, the cornerstone in the evaluation of delirium remains the history and physical examination. After a thorough evaluation, laboratory testing and diagnostic imaging may be warranted but should be individualized on a case-by-case basis. It may be helpful to keep in mind the five leading causes of delirium: (1) fluid/electrolyte disturbances, (2) infection, (3) medication toxicity, (4) metabolic derangement, and (5) sensory and environmental disturbance.


Aug 17, 2016 | Posted by in PEDIATRICS | Comments Off on DELIRIUM

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