Osteosarcomas (n = 157)
No.
%
Age at diagnosis (years)
Median
13.3
Range
(0–44)
Sex
Female
68
43.3
Male
89
56.7
Location
Proximal femur
9
5.7
Distal femur
79
50.3
Proximal tibia
39
24.8
Distal tibia
11
7
Proximal fibula
5
3.2
Proximal humerus
11
7
Distal humerus
2
1.3
Distal radio
1
0.6
Necrosis
Good (>90 %)
59
37.6
Poor (<90 %)
86
54.8
Not available
12
7.6
Histologic subtype
Osteoblastic
132
84.1
Chondroblastic
16
10.2
Fibroblastic
3
1.9
Telangiectasic
6
3.8
Metastasis at diagnosis
No
105
66.9
Yes
52
33.1
Status
Alive
101
64.3
Dead
48
30.6
Not available
8
5.1
Follow-up (months)
Mean
102
Median
69.5
Range
(2.6–363.7)
8.3 Results
The tumor crossed the physis in 56 % (89/157) of patients. Comparison of patients in whom tumors crossed the physis and patients in whom tumors did not revealed statistically significant differences in age, time from initial symptoms to start of treatment, presence of metastases at diagnosis and outcome (Table 8.2).
Table 8.2
Differences between patients grouped according to whether the tumor crossed the physis or not. (Contingency tables)
|
Physis crossed (%) |
Physis not crossed (%) |
||
|---|---|---|---|
|
Number |
89 (56 %) |
68 (44 %) |
|
|
Mean age |
13.4 |
11.9 |
p = 0.05 |
|
Diagnostic delaya |
4 months |
2 months |
p < 0.0001 |
|
Metastasis at diagnosis |
37 (42 %) |
15 (22 %) |
p = 0.04
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