Chapter 98 Abnormal Pap Test Result: Low-Grade Squamous Intraepithelial Lesion and High-Grade Squamous Intraepithelial Lesion
INTRODUCTION
Description: Low-grade squamous intraepithelial lesions (LGSIL) encompass changes associated with human papillomavirus (HPV), mild dysplasia, and cervical intraepithelial neoplasia (CIN) I. High-grade squamous intraepithelial lesions (HGSIL) include CIN II and III and carcinoma in situ (CIS).
ETIOLOGY AND PATHOGENESIS
Causes: HPV appears to be responsible for the development of cervical dysplasia. Although as many as 70% of invasive cervical cancers have HPV serotypes 16 or 18 present, these types may be detected in patients with LGSIL as well. Normal patients have HPV prevalence rates that vary from 10% to 50%, depending on the study technique and population evaluated.
